Pulmonary/Critical Care Service (MCHE-MDP), Department of Medicine, Womack Army Medical Center, 2817 Reilly Rd, Fort Bragg, NC, 28310, USA.
Environmental Pathology, The Joint Pathology Center, National Capitol Region Medical Directorate, Defense Health Agency, Silver Spring, MD, USA.
Lung. 2017 Aug;195(4):507-515. doi: 10.1007/s00408-017-0009-2. Epub 2017 May 23.
The current understanding of associations between lung disease and military deployment to Southwest Asia, including Iraq and Afghanistan, is both controversial and limited. We sought to clarify the relation between military deployment and biopsy-proven lung disease.
Retrospective data were analyzed for military personnel with non-neoplastic lung biopsies evaluated at the Armed Forces Institute of Pathology or Joint Pathology Center (January 2005 to December 2012).
Of 391 subjects, 137 (35.0%) had deployed to Southwest Asia prior to biopsy. Compared to non-deployed subjects, those deployed were younger (median age 37 vs. 51 years) with higher representation of African Americans (30.0 vs. 16.9%). Deployed patients were more likely diagnosed with non-necrotizing granulomas (OR 2.4). Non-deployed subjects had higher frequency of idiopathic interstitial pneumonias, particularly organizing pneumonia. Prevalence of small airways diseases including constrictive bronchiolitis was low.
This study provides a broader understanding of diversity of biopsy-proven non-neoplastic lung disease as it relates to military deployment to Southwest Asia and importantly did not show an increased prevalence of small airway disease to include constrictive bronchiolitis.
目前，对于与军事部署到西南亚（包括伊拉克和阿富汗）相关的肺部疾病的理解既有争议又有限。我们试图阐明军事部署与经活检证实的肺部疾病之间的关系。
对在武装部队病理学研究所或联合病理学中心（2005 年 1 月至 2012 年 12 月）接受非肿瘤性肺活检的军事人员进行回顾性数据分析。
在 391 名研究对象中，有 137 名（35.0%）在活检前曾部署到西南亚。与未部署的研究对象相比，部署的研究对象年龄更小（中位数年龄 37 岁 vs. 51 岁），非裔美国人的比例更高（30.0% vs. 16.9%）。部署患者更可能被诊断为非坏死性肉芽肿（OR 2.4）。未部署的研究对象中非特异性间质性肺炎的发生率更高，尤其是机化性肺炎。小气道疾病（包括缩窄性细支气管炎）的患病率较低。
本研究更全面地了解了与军事部署到西南亚相关的经活检证实的非肿瘤性肺部疾病的多样性，重要的是，并未显示小气道疾病（包括缩窄性细支气管炎）的患病率增加。
