Jacoby R O, Bhatt P N
J Infect Dis. 1976 Aug;134(2):158-65. doi: 10.1093/infdis/134.2.158.
Adult C3H/RV mice were highly resistant and adult C3H/He mice were highly susceptible to lethal encephalitis after intraperitoneal inoculation of Banzi virus (flavivirus), but the infectivity of the virus was the same for both strains of mice. Yields of virus were similar from lymphoid tissues of C3H/He and C3H/RV adult mice, but titers of virus in the brain were significantly lower in C3H/RV mice. Lesions of encephalitis developed in both strains but remained mild and self-limiting in C3H/RV mice, whereas widespread necrosis occurred in the brains of C3H/He mice. Resistance to lethal infection after intraperitoneal inoculation developed postnatally in C3H/RV mice and did not reach significant levels until mice were at least four weeks old. Mortality rates among C3H/RV and C3H/He mice were comparable after intracerebral inoculation of virus. Yields of virus, brain lesions, and immunofluorescent staining patterns for viral antigen were similar in intracerebrally inoculated C3H/He and C3H/RV mice. Results indicate that tissues of resistant and susceptible mice in vivo can support replication of Banzi virus about equally well. Thus, genetic resistance to lethal infection with Banzi virus in these strains of mice does not seem to be solely dependent on resistance of tissues to viral replication.
成年C3H/RV小鼠对腹腔接种班齐病毒（黄病毒）后的致死性脑炎具有高度抗性，而成年C3H/He小鼠则高度易感，但该病毒对这两种品系小鼠的感染性相同。C3H/He和C3H/RV成年小鼠的淋巴组织中病毒产量相似，但C3H/RV小鼠脑中的病毒滴度显著较低。两种品系小鼠均出现脑炎病变，但C3H/RV小鼠的病变仍较轻微且具有自限性，而C3H/He小鼠脑内则发生广泛坏死。C3H/RV小鼠腹腔接种后对致死性感染的抗性在出生后形成，直至小鼠至少4周龄时才达到显著水平。脑内接种病毒后，C3H/RV和C3H/He小鼠的死亡率相当。脑内接种的C3H/He和C3H/RV小鼠的病毒产量、脑病变以及病毒抗原的免疫荧光染色模式相似。结果表明，抗性和易感小鼠的体内组织对班齐病毒复制的支持能力大致相同。因此，这些品系小鼠对班齐病毒致死性感染的遗传抗性似乎并非仅取决于组织对病毒复制的抗性。
