Satoh M, Ishihara K, Iwama T, Takagi H
Neurosci Lett. 1986 Jul 24;68(2):216-20. doi: 10.1016/0304-3940(86)90145-x.
The effects of aniracetam, a nootropic drug, and midazolam, which produces amnesia, on the long-term potentiation (LTP) of population spikes was investigated using hippocampal slices (CA3 area) from the guinea pig. Aniracetam at concentrations of 10(-7) and 10(-8) M, but not at 10(-6) M, significantly augmented LTP. On the other hand, midazolam (10(-9) M) significantly suppressed LTP. The suppressive effect was antagonized by Ro 15-1788 (10(-8) M). Both drugs did not affect the population spikes in the absence of tetanic stimulation at those concentrations. It was suggested that in vitro application of LTP is a feasible model system for evaluating the nootropic activity of drugs.
使用豚鼠海马切片（CA3区）研究了促智药阿尼西坦和产生失忆作用的咪达唑仑对群体峰电位长时程增强（LTP）的影响。浓度为10^(-7) M和10^(-8) M的阿尼西坦可显著增强LTP，但10^(-6) M时则无此作用。另一方面，咪达唑仑（10^(-9) M）可显著抑制LTP。Ro 15-1788（10^(-8) M）可拮抗这种抑制作用。在这些浓度下，两种药物在无强直刺激时均不影响群体峰电位。提示LTP的体外应用是评估药物促智活性的一种可行的模型系统。
