Johansen Cornelia, Mariani Claire, Mueller Ralf S
Centre for Clinical Veterinary Medicine, Ludwig Maximilian University, Veterinaerstr. 13, Munich, 80539, Germany.
Royal Canin SAS, Aimargues, F-30470, France.
Vet Dermatol. 2017 Oct;28(5):473-e109. doi: 10.1111/vde.12455. Epub 2017 May 22.
Adverse food reaction (AFR) is an important differential diagnosis for the pruritic dog. It is usually diagnosed by feeding an elimination diet with a novel protein and carbohydrate source for eight weeks followed by subsequent food provocation. A previous study demonstrated that patch testing dogs with foods had a high sensitivity and negative predictability for selection of elimination diet ingredients.
HYPOTHESIS/OBJECTIVES: The aim of this study was to investigate patch testing with proteins, carbohydrates and dry commercial dog food in dogs to determine whether there was value in patch testing to aid the diagnosis of canine adverse food reaction.
Twenty five privately owned dogs, with confirmed AFR, underwent provocation trials with selected food antigens and patch testing.
For proteins, carbohydrates and dry dog food the sensitivity of patch testing was 100%, 70% and 22.2%, respectively; the negative predictive values of patch testing were 100%, 79% and 72%. The positive predictive values of patch testing for proteins and carbohydrates were 75% and 74%, respectively.
This study confirmed that patch testing may be useful for the selection of a suitable protein source for an elimination diet in dogs with suspected AFR, but not as a diagnostic tool for canine AFR. Results for proteins are more reliable than for carbohydrates and the majority of positive patch test reactions were observed with raw protein. Patch testing with commercial dog food does not seem to be useful.
食物不良反应（AFR）是瘙痒犬的重要鉴别诊断。通常通过喂食含新蛋白质和碳水化合物来源的排除性饮食八周，随后进行食物激发试验来诊断。先前的一项研究表明，对犬进行食物斑贴试验对于选择排除性饮食成分具有较高的敏感性和阴性预测值。
假设/目的：本研究的目的是调查对犬进行蛋白质、碳水化合物和市售干狗粮斑贴试验，以确定斑贴试验在辅助诊断犬类食物不良反应方面是否有价值。
25只确诊为AFR的家养犬接受了选定食物抗原的激发试验和斑贴试验。
对于蛋白质、碳水化合物和干狗粮，斑贴试验的敏感性分别为100%、70%和22.2%；斑贴试验的阴性预测值分别为100%、79%和72%。蛋白质和碳水化合物斑贴试验的阳性预测值分别为75%和74%。
本研究证实，斑贴试验可能有助于为疑似AFR的犬选择合适的排除性饮食蛋白质来源，但不能作为犬类AFR的诊断工具。蛋白质的结果比碳水化合物更可靠，大多数阳性斑贴试验反应出现在生蛋白质上。对市售狗粮进行斑贴试验似乎没有用处。
