Van der Sluijs E, Van der Weijden G A, Hennequin-Hoenderdos N L, Slot D E
Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands.
Int J Dent Hyg. 2018 Feb;16(1):92-102. doi: 10.1111/idh.12291. Epub 2017 May 24.
To compare the effects of a regimen consisting of a tooth/tongue gel, tongue cleaner and mouthwash with the effects of using standard fluoride dentifrice on the organoleptic oral malodour score (ORG) and volatile sulphur compounds (VSCs).
A total, 66 non-dental students participated in a 3-week parallel, single-blind, randomized, controlled clinical trial. The test group used a tongue cleaner, a tooth/tongue gel and mouthwash containing amine fluoride/stannous fluoride and zinc lactate as oral malodour counteractive. The control group used a standard fluoride dentifrice. Measurements were taken in the morning at baseline, at days 1, 7 and 21. The primary outcome was the ORG score. The secondary outcome, the VSC measurement, was assessed using OralChroma™ (H S, CH SH, (CH ) S) and Halimeter . Tongue coating thickness and tongue discoloration were scored. At baseline and day 21, the participants' self-perceptions were assessed.
At day 1 for the ORG, H S, CH SH and Halimeter readings, a significant decrease was observed in the test group. At day 21, the decrease in H S and the Halimeter outcomes were maintained for the test group, and a significant increase in tongue surface discoloration was observed. The test group evaluated their "morning breath upon awakening" as significantly better (P=.001) after 21 days.
A significant overnight effect on morning oral malodour was observed for most of the parameters in favour of the test group. At day 21, the effect of prolonged use was significant for H S and the Halimeter readings, although not for the primary ORG outcome parameter.
比较一种由牙齿/舌头凝胶、舌刷和漱口水组成的方案与使用标准含氟牙膏对口腔异味感官评分（ORG）和挥发性硫化物（VSC）的影响。
共有66名非牙科专业学生参与了一项为期3周的平行、单盲、随机对照临床试验。试验组使用舌刷、含有胺氟化物/氟化亚锡和乳酸锌的牙齿/舌头凝胶及漱口水来对抗口腔异味。对照组使用标准含氟牙膏。在基线、第1天、第7天和第21天的早晨进行测量。主要观察指标为ORG评分。次要观察指标VSC测量采用OralChroma™（H₂S、CH₃SH、(CH₃)₂S）和Halimeter进行评估。对舌苔厚度和舌色进行评分。在基线和第21天，评估参与者的自我认知。
在第1天，试验组的ORG、H₂S、CH₃SH和Halimeter读数显著下降。在第21天，试验组的H₂S下降和Halimeter测量结果得以维持，且观察到舌面变色显著增加。试验组在21天后对其“醒来时的晨口气”评价明显更好（P = 0.001）。
对于大多数参数，观察到试验组对早晨口腔异味有显著的夜间改善效果。在第21天，长期使用对H₂S和Halimeter读数有显著效果，尽管对主要的ORG观察指标参数无显著效果。
