Janzen E G, Towner R A, Haire D L
Department of Chemistry and Biochemistry, Guelph-Waterloo Centre for Graduate Work in Chemistry, University of Guelph, Ontario, Canada.
Free Radic Res Commun. 1987;3(6):357-64. doi: 10.3109/10715768709088076.
The spin trapping chemistry of carbon tetrachloride has been previously investigated in rat liver, both in vitro and in vivo. In addition to the trichloromethyl radical, both a 'carbon-centered' and an 'oxygen-centered' radical have been detected in vitro. These spin adducts have been assigned to 'lipid' and 'lipid oxyl' radicals. However, no specific structural characterization has been provided to date. The spin trapping chemistry of this system was reinvestigated with the use of deuterated alpha-phenyl N-tert-butyl nitrones to obtain better spectral resolution. Results indicate that the PBN trapped carbon-centered lipid radical is of a primary alkyl type.
四氯化碳的自旋捕集化学此前已在大鼠肝脏中进行了体外和体内研究。除了三氯甲基自由基外，在体外还检测到了一个“碳中心”自由基和一个“氧中心”自由基。这些自旋加合物已被认定为“脂质”和“脂质氧基”自由基。然而，迄今为止尚未提供具体的结构表征。利用氘代α-苯基N-叔丁基硝酮重新研究了该体系的自旋捕集化学，以获得更好的光谱分辨率。结果表明，PBN捕获的碳中心脂质自由基是伯烷基类型的。
