Zhang Ming, Saint-Germain Camille, He Guiling, Sun Raymond Wai-Yin
Department of Chemistry, Shantou University 243 Da Xue Road, Shantou, Guangdong 515063, China.
Paul Sabatier University, 118 Route de Narbonne, F-31062 Toulouse, Toulouse, France.
Curr Med Chem. 2018 Feb 12;25(4):493-505. doi: 10.2174/0929867324666170511152441.
Although cisplatin and a number of platinum complexes have widely been used for the treatment of neoplasia, patients receiving these treatments have frequently suffered from their severe toxic side effects, the development of resistance with consequent relapse. In the recent decades, numerous complexes of coinage metals including that of gold, copper and silver have been reported to display promising in vitro and/or in vivo anti-cancer activities as well as potent activities towards cisplatin-resistant tumors. Nevertheless, the medical development of these metal complexes has been hampered by their instability in aqueous solutions and the nonspecific binding in biological systems.
One of the approaches to overcome these problems is to design and develop adequate drug delivery systems (DDSs) for the transport of these complexes. By functionalization, encapsulation or formulation of the metal complexes, several types of DDSs have been reported to improve the desired pharmacological profile of the metal complexes, improving their overall stability, bioavailability, anti-cancer activity and reducing their toxicity towards normal cells.
In this review, we summarized the recent findings for different DDSs for various anti- cancer active complexes of some coinage metals.
尽管顺铂和许多铂配合物已广泛用于肿瘤治疗，但接受这些治疗的患者经常遭受其严重的毒副作用，以及产生耐药性并随之复发。近几十年来，据报道许多包括金、铜和银在内的硬币金属配合物在体外和/或体内显示出有前景的抗癌活性以及对顺铂耐药肿瘤的强效活性。然而，这些金属配合物的医学发展受到其在水溶液中的不稳定性以及在生物系统中的非特异性结合的阻碍。
克服这些问题的方法之一是设计和开发用于运输这些配合物的合适药物递送系统（DDS）。通过对金属配合物进行功能化、封装或制剂化，已报道了几种类型的DDS以改善金属配合物所需的药理学特性，提高其整体稳定性、生物利用度、抗癌活性并降低其对正常细胞的毒性。
在本综述中，我们总结了针对某些硬币金属的各种抗癌活性配合物的不同DDS的最新研究结果。
