Wang Xueyin, Strizich Garrett, Hua Simin, Sotres-Alvarez Daniela, Buelna Christina, Gallo Linda C, Gellman Marc D, Mossavar-Rahmani Yasmin, O'Brien Matthew J, Stoutenberg Mark, Wang Tao, Avilés-Santa M Larissa, Kaplan Robert C, Qi Qibin
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
J Am Heart Assoc. 2017 May 25;6(6):e004324. doi: 10.1161/JAHA.116.004324.
Cardiovascular disease (CVD) risk factor control is a cornerstone of diabetes mellitus management. Little is known about relationships of objectively measured sedentary time and physical activity with major CVD risk factor control in individuals with diabetes mellitus. We examined associations of objectively measured sedentary time and moderate-to-vigorous physical activity with reaching major CVD risk factor control goals among US Hispanic/Latino adults with diabetes mellitus.
This cross-sectional analysis included 1699 participants with diabetes mellitus from the Hispanic Community Health Study/Study of Latinos (2008-2011). Logistic regression models were used to estimate the odds ratios (ORs) of meeting the following 5 major CVD risk factor control goals: hemoglobin A <7.0%; systolic/diastolic blood pressure <140/80 mm Hg; triglycerides <150 mg/dL; low-density lipoprotein cholesterol <100 mg/dL; and high-density lipoprotein cholesterol >40/50 mg/dL for men/women. After adjustment for covariates including moderate-to-vigorous physical activity, less sedentary time was associated with increased odds of reaching hemoglobin A (OR=1.76 [95% CI: 1.10, 2.82]) and triglyceride control goals (OR=2.16 [1.36, 3.46]), and reaching ≥3 CVD risk factor control goals (OR=2.08 [1.34, 3.23]) (all ORs for comparisons of extreme tertiles of sedentary time). Moderate-to-vigorous physical activity was not associated with reaching any CVD risk factor control goals. Substituting 60-min/day of sedentary time with light-intensity physical activity was associated with increased odds of reaching hemoglobin A (OR=1.18 [1.04, 1.35]), high-density lipoprotein cholesterol (OR=1.17 [1.04, 1.32]), and triglyceride (OR=1.20 [1.05, 1.36]) control goals.
Among US Hispanic/Latino adults with diabetes mellitus, less sedentary time, but not moderate-to-vigorous physical activity, was associated with improved CVD risk factor control, specifically in reaching hemoglobin A and triglyceride control goals.
心血管疾病（CVD）危险因素的控制是糖尿病管理的基石。对于糖尿病患者，客观测量的久坐时间和身体活动与主要CVD危险因素控制之间的关系知之甚少。我们研究了美国西班牙裔/拉丁裔糖尿病成年人中，客观测量的久坐时间和中度至剧烈身体活动与实现主要CVD危险因素控制目标之间的关联。
这项横断面分析纳入了西班牙裔社区健康研究/拉丁裔研究（2008 - 2011年）中的1699名糖尿病参与者。采用逻辑回归模型估计达到以下5个主要CVD危险因素控制目标的比值比（OR）：糖化血红蛋白A<7.0%；收缩压/舒张压<140/80 mmHg；甘油三酯<150 mg/dL；低密度脂蛋白胆固醇<100 mg/dL；男性/女性高密度脂蛋白胆固醇>40/50 mg/dL。在调整包括中度至剧烈身体活动在内的协变量后，久坐时间减少与达到糖化血红蛋白A（OR = 1.76 [95% CI：1.10, 2.82]）和甘油三酯控制目标（OR = 2.16 [1.36, 3.46]）以及达到≥3个CVD危险因素控制目标（OR = 2.08 [1.34, 3.23]）的几率增加相关（所有OR用于比较久坐时间的极端三分位数）。中度至剧烈身体活动与达到任何CVD危险因素控制目标均无关联。用轻度身体活动替代每天60分钟的久坐时间与达到糖化血红蛋白A（OR = 1.18 [1.04, 1.35]）、高密度脂蛋白胆固醇（OR = 1.17 [1.04, 1.32]）和甘油三酯（OR = 1.20 [1.05, 1.36]）控制目标的几率增加相关。
在美国西班牙裔/拉丁裔糖尿病成年人中，久坐时间减少而非中度至剧烈身体活动与改善CVD危险因素控制相关，特别是在达到糖化血红蛋白A和甘油三酯控制目标方面。
