美国西班牙裔/拉丁裔成年人中客观测量的久坐时间与心脏代谢生物标志物：西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）
Objectively Measured Sedentary Time and Cardiometabolic Biomarkers in US Hispanic/Latino Adults: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
作者信息
Qi Qibin, Strizich Garrett, Merchant Gina, Sotres-Alvarez Daniela, Buelna Christina, Castañeda Sheila F, Gallo Linda C, Cai Jianwen, Gellman Marc D, Isasi Carmen R, Moncrieft Ashley E, Sanchez-Johnsen Lisa, Schneiderman Neil, Kaplan Robert C
机构信息
From Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Bronx, NY (Q.Q., G.S., C.R.I., R.C.K.); San Diego State University, Graduate School of Public Health, San Diego, CA (G.M., C.B., S.F.C.); University of North Carolina, Collaborative Studies Coordinating Center, Department of Biostatistics, Chapel Hill, NC (D.S.-A., J.C.); San Diego State University, Department of Psychology, San Diego, CA (L.C.G.); University of Miami, Department of Psychology, Miami, FL (M.D.G., A.E.M., N.S.); and University of Illinois at Chicago, Department of Psychiatry, Chicago, IL (L.S.-J.).
出版信息
Circulation. 2015 Oct 20;132(16):1560-9. doi: 10.1161/CIRCULATIONAHA.115.016938. Epub 2015 Sep 28.
BACKGROUND
Sedentary behavior is recognized as a distinct construct from lack of moderate-vigorous physical activity and is associated with deleterious health outcomes. Previous studies have primarily relied on self-reported data, whereas data on the relationship between objectively measured sedentary time and cardiometabolic biomarkers are sparse, especially among US Hispanics/Latinos.
METHODS AND RESULTS
We examined associations of objectively measured sedentary time (via Actical accelerometers for 7 days) and multiple cardiometabolic biomarkers among 12 083 participants, aged 18 to 74 years, from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hispanics/Latinos of diverse backgrounds (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) were recruited from 4 US cities between 2008 and 2011. Sedentary time (<100 counts/min) was standardized to 16 hours/d of wear time. The mean sedentary time was 11.9 hours/d (74% of accelerometer wear time). After adjustment for moderate-vigorous physical activity and confounding variables, prolonged sedentary time was associated with decreased high-density lipoprotein cholesterol (P=0.04), and increased triglycerides, 2-hour glucose, fasting insulin, and homeostatic model assessment of insulin resistance (all P<0.0001). These associations were generally consistent across age, sex, Hispanic/Latino backgrounds, and physical activity levels. Even among individuals meeting physical activity guidelines, sedentary time was detrimentally associated with several cardiometabolic biomarkers (diastolic blood pressure, high-density lipoprotein cholesterol, fasting and 2-hour glucose, fasting insulin and homeostatic model assessment of insulin resistance; all P<0.05).
CONCLUSIONS
Our large population-based, objectively derived data showed deleterious associations between sedentary time and cardiometabolic biomarkers, independent of physical activity, in US Hispanics/Latinos. Our findings emphasize the importance of reducing sedentary behavior for the prevention of cardiometabolic diseases, even in those who meet physical activity recommendations.
背景
久坐行为被认为是一种有别于缺乏中等强度至剧烈身体活动的独特概念，且与不良健康后果相关。以往研究主要依赖自我报告数据，而关于客观测量的久坐时间与心血管代谢生物标志物之间关系的数据较为稀少，尤其是在美国西班牙裔/拉丁裔人群中。
方法与结果
我们在西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）中，对12083名年龄在18至74岁的参与者进行了研究，通过Actical加速度计客观测量久坐时间（持续7天），并检测多种心血管代谢生物标志物。2008年至2011年间，从美国4个城市招募了不同背景（中美洲、古巴、多米尼加、墨西哥、波多黎各和南美洲）的西班牙裔/拉丁裔人群。久坐时间（每分钟计数<100次）按照每天16小时佩戴时间进行标准化。平均久坐时间为每天11.9小时（占加速度计佩戴时间的74%）。在对中等强度至剧烈身体活动和混杂变量进行调整后，久坐时间延长与高密度脂蛋白胆固醇降低相关（P = 0.04），与甘油三酯、2小时血糖、空腹胰岛素以及胰岛素抵抗稳态模型评估升高相关（所有P<0.0001）。这些关联在年龄、性别、西班牙裔/拉丁裔背景以及身体活动水平方面总体上是一致的。即使在达到身体活动指南要求的个体中，久坐时间也与多种心血管代谢生物标志物存在有害关联（舒张压、高密度脂蛋白胆固醇、空腹和2小时血糖、空腹胰岛素以及胰岛素抵抗稳态模型评估；所有P<0.05）。
结论
我们基于大量人群的客观数据表明，在美国西班牙裔/拉丁裔人群中，久坐时间与心血管代谢生物标志物之间存在有害关联，且独立于身体活动。我们的研究结果强调了减少久坐行为对预防心血管代谢疾病的重要性，即使对于那些达到身体活动建议的人也是如此。
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