Department of Environmental and Occupational Health, National Cheng Kung University Medical College, 138 Sheng-Li Road, Tainan 70428, Taiwan.
Biomed Res Int. 2013;2013:905670. doi: 10.1155/2013/905670. Epub 2013 Apr 4.
Allergic asthma is one of the most common chronic inflammatory diseases of airways. Severe asthma may lead to hospitalization and death. Sesame oil is a natural product with anti-inflammatory property. However, the effect of sesame oil on allergic asthma has never been studied.
We investigate the effect of sesame oil on pulmonary inflammation in allergic asthma model.
Allergic airway inflammation was induced by sensitizing with two doses of 10 mg ovalbumin (OVA) and then challenged with 1% OVA nebulizer exposure (1 h/day) for 3 days. Sesame oil (0.25, 0.5, or 1 mL/kg/day) was given orally 30 min before each challenge. Samples were collected 24 h after the last challenge.
Data showed that sesame oil inhibited pulmonary edema and decreased interleukin (IL)-1 β and IL-6 levels in bronchoalveolar lavage fluid in OVA-treated mice. Sesame oil also decreased pulmonary nitrite level, inducible nitric oxide synthase expression, and neutrophil infiltration induced by OVA. Further, sesame oil decreased serum IgE level in OVA-treated mice.
Sesame oil may attenuate pulmonary edema and bronchial neutrophilic inflammation by inhibiting systemic IgE level in allergic asthma.
过敏性哮喘是最常见的气道慢性炎症性疾病之一。严重的哮喘可能导致住院和死亡。芝麻油是一种具有抗炎特性的天然产物。然而，芝麻油对过敏性哮喘的影响从未被研究过。
我们研究芝麻油对过敏性哮喘模型中肺炎症的影响。
通过两次给予 10mg 卵清蛋白（OVA）致敏，然后用 1%OVA 雾化器暴露（每天 1 小时）3 天来诱导过敏性气道炎症。芝麻油（0.25、0.5 或 1mL/kg/天）在每次暴露前 30 分钟口服给予。在最后一次暴露后 24 小时收集样本。
数据显示，芝麻油抑制了 OVA 处理小鼠的肺水肿，并降低了支气管肺泡灌洗液中白细胞介素（IL）-1β和 IL-6 的水平。芝麻油还降低了由 OVA 诱导的肺亚硝酸盐水平、诱导型一氧化氮合酶表达和中性粒细胞浸润。此外，芝麻油降低了 OVA 处理小鼠的血清 IgE 水平。
芝麻油可能通过抑制过敏性哮喘中的血清 IgE 水平来减轻肺水肿和支气管中性粒细胞炎症。
