School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China.
Dalton Trans. 2017 Jun 13;46(23):7434-7440. doi: 10.1039/c7dt01184a.
An elegant atomic layer deposition (ALD) method has been employed for the controllable preparation of a uniform FeO-coated graphene nanostructure (FeO@graphene). The FeO coating thickness of the FeO@graphene nanostructure can be tuned by varying the cycle number of FeO ALD. The produced FeO@graphene composites are characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy and cyclic voltammetry (CV). It is revealed that FeO is effectively deposited on the surface of graphene. Combined with the high affinity and specificity of an aptamer, a simple, rapid and sensitive electrochemical aptasensor was successfully fabricated for thrombin detection. The resulting electrochemical aptasensor displays a linear response to thrombin in the 1.0 × 10 to 4.0 × 10 M concentration range with the detection limit of 1.0 × 10 M (at an S/N of 3). The described controllable multifunctional graphene nanomaterials from ALD are expected to be applied in a biosensing platform which will exhibit wide applications in biological, medical, and environmental fields.
采用优雅的原子层沉积（ALD）方法，可可控地制备均匀的 FeO 涂层石墨烯纳米结构（FeO@graphene）。通过改变 FeO ALD 的循环次数，可以调节 FeO@graphene 纳米结构的 FeO 涂层厚度。所制备的 FeO@graphene 复合材料通过透射电子显微镜（TEM）、X 射线光电子能谱（XPS）、拉曼光谱和循环伏安法（CV）进行了表征。结果表明，FeO 有效地沉积在石墨烯的表面上。结合适体的高亲和力和特异性，成功地制备了用于检测凝血酶的简单、快速和灵敏的电化学适体传感器。所得的电化学适体传感器在 1.0×10 到 4.0×10 M 的浓度范围内对凝血酶表现出线性响应，检测限为 1.0×10 M（信噪比为 3）。预计来自 ALD 的这种可控多功能石墨烯纳米材料将应用于生物传感平台，这将在生物、医学和环境领域得到广泛应用。
