Controllable n-FeO@graphene nanomaterials by ALD applied in an aptasensor with enhanced electrochemical performance for thrombin detection.

An elegant atomic layer deposition (ALD) method has been employed for the controllable preparation of a uniform FeO-coated graphene nanostructure (FeO@graphene). The FeO coating thickness of the FeO@graphene nanostructure can be tuned by varying the cycle number of FeO ALD. The produced FeO@graphene composites are characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy and cyclic voltammetry (CV). It is revealed that FeO is effectively deposited on the surface of graphene. Combined with the high affinity and specificity of an aptamer, a simple, rapid and sensitive electrochemical aptasensor was successfully fabricated for thrombin detection. The resulting electrochemical aptasensor displays a linear response to thrombin in the 1.0 × 10 to 4.0 × 10 M concentration range with the detection limit of 1.0 × 10 M (at an S/N of 3). The described controllable multifunctional graphene nanomaterials from ALD are expected to be applied in a biosensing platform which will exhibit wide applications in biological, medical, and environmental fields.