Fernandez Silvina, Ledo Camila, Lattar Santiago, Noto Llana Mariángeles, Bertelli Andrea Mendoza, Di Gregorio Sabrina, Sordelli Daniel O, Gómez Marisa I, Mollerach Marta E
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Microbiología, and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Junín 956, C1113AAD, Buenos Aires, Argentina.
Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPaM), Universidad de Buenos Aires and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Paraguay 2155, C1121ABG, Buenos Aires, Argentina.
Int J Med Microbiol. 2017 Jun;307(4-5):191-199. doi: 10.1016/j.ijmm.2017.05.003. Epub 2017 May 15.
Community-acquired methicillin resistant Staphylococcus aureus emerged as a worldwide health problem in the last few years. In Argentina, it is found in 70% of skin and skin structure infections in previously healthy adult patients and causes severe invasive diseases. The ST30-SCCmecIVc-spat019 clone is predominant in adult infections and has displaced the previously prevalent ST5-SCCmecIVa-spat311 clone in community settings. In the present work we compared the virulence of both clones in order to explain the displacement, and found that ST30-IVc is associated with invasive infections in adult patients from Argentina and possesses a different virulence-associated genes profile compared to ST5-IVa. A representative strain of ST30 lineage has a more aggressive behavior in animal models of infection and expresses higher level of Fibronectin binding protein A coding gene, which could enhance the bacterial invasion capacity.
社区获得性耐甲氧西林金黄色葡萄球菌在过去几年中已成为一个全球性的健康问题。在阿根廷，在既往健康的成年患者中，70%的皮肤及皮肤结构感染中可发现该菌，并且它会引发严重的侵袭性疾病。ST30-SCCmecIVc-spat019克隆在成人感染中占主导地位，并且在社区环境中已取代了先前流行的ST5-SCCmecIVa-spat311克隆。在本研究中，我们比较了这两种克隆的毒力以解释这种取代现象，并且发现ST30-IVc与阿根廷成年患者的侵袭性感染相关，与ST5-IVa相比，其具有不同的毒力相关基因谱。ST30谱系的一个代表性菌株在感染动物模型中具有更强的侵袭性，并且表达更高水平的纤连蛋白结合蛋白A编码基因，这可能会增强细菌的侵袭能力。
