Miyamura K, Yamashita K, Takeda N, Ogino T, Utagawa E, Yamazaki S, Fukumura K, Uehara T, Shinjo N
Central Virus Diagnostic Laboratory, National Institute of Health, Tokyo.
Jpn J Med Sci Biol. 1988 Aug;41(4):159-74. doi: 10.7883/yoken1952.41.159.
Epidemics of acute hemorrhagic conjunctivitis due to a coxsackievirus A24 variant occurred in July-November, 1985 and August-October, 1986 in Okinawa Prefecture, Japan. This is the first report of an acute hemorrhagic conjunctivitis epidemic due to a coxsackievirus A24 variant in Japan The epidemic involved most islands of the prefecture. The prefectural surveillance center was notified of 9,952 cases in 1985 and 6,096 cases in 1986 from three sentinel eye clinics. The neutralizing antibody-positive rate against the coxsackievirus A24 variant of the serum samples collected before and immediately after the 1985 epidemic rose from 1.0% to 8.5%. The coxsackievirus A24 variant was isolated from 48 out of 68 conjunctival swabs collected during the epidemics. The isolates were indistinguishable antigenically in the plaque reduction test from the prototype strain, EH24/70, but had a markedly distinct oligonucleotide pattern.
1985年7月至11月以及1986年8月至10月，日本冲绳县发生了由A24型柯萨奇病毒变种引起的急性出血性结膜炎流行。这是日本首次关于由A24型柯萨奇病毒变种引起急性出血性结膜炎流行的报告。此次流行涉及该县的大多数岛屿。1985年，来自三个定点眼科诊所的9952例病例以及1986年的6096例病例被报告至该县监测中心。1985年流行之前和之后立即采集的血清样本中，针对A24型柯萨奇病毒变种的中和抗体阳性率从1.0%升至8.5%。在流行期间采集的68份结膜拭子中，有48份分离出了A24型柯萨奇病毒变种。在蚀斑减少试验中，分离株在抗原性上与原型毒株EH24/70无法区分，但具有明显不同的寡核苷酸模式。
