Liu Jie, Chen Chao, Ji Shenglu, Liu Qian, Ding Dan, Zhao Dan, Liu Bin
Department of Chemical and Biomolecular Engineering , National University of Singapore , 4 Engineering Drive 4 , 117585 , Singapore . Email:
State Key Laboratory of Medicinal Chemical Biology , Key Laboratory of Bioactive Materials , Ministry of Education , College of Life Sciences , Nankai University , Tianjin 300071 , P. R. China . Email:
Chem Sci. 2017 Apr 1;8(4):2782-2789. doi: 10.1039/c6sc04384d. Epub 2017 Jan 20.
Near infrared (NIR) fluorescence imaging (700-900 nm) is a promising technology in preclinical and clinical tumor diagnosis and therapy. The availability of excellent NIR fluorescent contrast agents is still the main barrier to implementing this technology. Herein, we report the design and synthesis of two series of NIR fluorescent molecules with long wavelength excitation and aggregation-induced emission (AIE) characteristics by fine-tuning their molecular structures and substituents. Further self-assembly between an amphiphilic block co-polymer and the obtained AIE molecules leads to AIE nanoparticles (AIE NPs), which have absorption maxima at 635 nm and emission maxima between 800 and 815 nm with quantum yields of up to 4.8% in aggregated states. and toxicity results demonstrate that the synthesized AIE NPs are biocompatible. Finally, the synthesized AIE NPs have been successfully used for image-guided tumor resection with a high tumor-to-normal tissue signal ratio of 7.2.
近红外（NIR）荧光成像（700 - 900纳米）是一种在临床前和临床肿瘤诊断及治疗中颇具前景的技术。优质近红外荧光造影剂的可得性仍是实施该技术的主要障碍。在此，我们通过精细调整分子结构和取代基，报告了两个具有长波长激发和聚集诱导发光（AIE）特性的近红外荧光分子系列的设计与合成。两亲性嵌段共聚物与所获得的AIE分子之间进一步的自组装形成了AIE纳米颗粒（AIE NPs），其在635纳米处有最大吸收峰，在800至815纳米之间有最大发射峰，聚集态下量子产率高达4.8%。 以及毒性结果表明合成的AIE NPs具有生物相容性。最后，合成的AIE NPs已成功用于图像引导的肿瘤切除，肿瘤与正常组织的信号比高达7.2。
