Mahmoudi Parisa, Veladi Hadi, Pakdel Firooz G
Department of Electrical Engineering, Payame Noor University, Tehran, Iran.
Microsystem Fabrication Lab, Faculty of Electrical Engineering, University of Tabriz, Tabriz, Iran.
J Med Signals Sens. 2017 Apr-Jun;7(2):71-79.
Comprehension of the brain function can be helpful for therapy of neurodegenerative diseases. The brain consists of various types of neuron sets, which organize in three-dimensional complex networks and form neural circuits underlying different behaviors. The circuits act based on the patterns that encode the brain functions. Recognition of the neural patterns requires methods to manipulate the neurons. Electrical stimulation may be the most common method. However, it has significant drawbacks including failure to identify specific neurons in experiments. As an alternative, optical stimulation is a new method that acts in combination with genetic approaches. The novel, optogenetic technology makes it feasible to manipulate either the specific cell types or the neural circuits. This is associated with minimum tissue damages as well as side effects. In this study, a new technology has been introduced, and then its optical and genetical tools have been investigated.
对脑功能的理解有助于神经退行性疾病的治疗。大脑由各种类型的神经元集合组成，这些神经元集合在三维复杂网络中组织起来，形成不同行为背后的神经回路。这些回路根据编码脑功能的模式发挥作用。识别神经模式需要操纵神经元的方法。电刺激可能是最常见的方法。然而，它有显著的缺点，包括在实验中无法识别特定的神经元。作为一种替代方法，光刺激是一种与基因方法结合使用的新方法。新颖的光遗传学技术使得操纵特定的细胞类型或神经回路成为可能。这与最小的组织损伤以及副作用相关。在本研究中，引入了一种新技术，然后对其光学和基因工具进行了研究。
