Nadi Maryam, Marandi Seyyed Mohammad, Esfarjani Fahimeh, Saleki Mohammad, Mohammadi Mahboobeh
Department of Exercise Physiology, University of Isfahan, Isfahan, Iran.
Department of Exercise Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2017 May 2;6:55. doi: 10.4103/2277-9175.205528. eCollection 2017.
Peripheral neuropathy is a common complaint of diabetes. This study aimed to determine the effects of 12 weeks combined training with Vitamin D supplement on improvement of sensory-motor neuropathy in women with diabetic neuropathy.
This clinical trial study conducted on 90 patients were selected and randomly divided into two groups. Finally, 81 adult females with diabetes type II (20-55 years old) were interred in this study. The control group had no training, but received Vitamin D. The experimental group received Vitamin D and 12 weeks training program (3 days a week, 60 min/session) including aerobic exercises, strength, and flexibility. Aerobic exercise intensity was set at 60-70% maximum heart rate and resistance training intensity was determined by 10 R.M. Michigan neuropathy questionnaire, reflex hammer and tuning fork 128 Hz used to screening tense of neuropathy (Michigan Neuropathy Screening Instrument) that were used for pretest and posttest.
Following 3 months combined training and supplementation with Vitamin D, had observed a significant reduction in numbness ( = 0.001), pain (0.002), tingling ( = 0.001), and weakness ( = 0.002) in the lower limb and also increases in sense of touch intervention ( = 0.005), detects the position of the fingers ( = 0.001) and vibration perception ( = 0.001) in tissues. Knee reflexes ( = 0.77) and ankles reflexes ( = 0.47) did not significantly change after interventions.
It seems that taking part in combined training and supplementation with Vitamin D can improve the symptoms of sensory-motor neuropathy.
周围神经病变是糖尿病患者常见的主诉。本研究旨在确定为期12周的联合训练与补充维生素D对改善糖尿病性神经病变女性感觉运动神经病变的影响。
本临床试验研究选取了90例患者并随机分为两组。最终，81名成年II型糖尿病女性（20 - 55岁）纳入本研究。对照组不进行训练，但补充维生素D。实验组接受维生素D及为期12周的训练计划（每周3天，每次60分钟），包括有氧运动、力量训练和柔韧性训练。有氧运动强度设定为最大心率的60 - 70%，阻力训练强度由10RM确定。使用密歇根神经病变问卷、反射锤和128Hz音叉用于筛查神经病变的严重程度（密歇根神经病变筛查工具），在训练前和训练后进行测试。
经过3个月的联合训练及补充维生素D后，观察到下肢麻木（P = 0.001）、疼痛（P = 0.002）、刺痛（P = 0.001）和无力（P = 0.002）显著减轻，同时组织中的触觉（P = 0.005）、手指位置感知（P = 0.001）和振动觉（P = 0.001）增强。干预后膝反射（P = 0.77）和踝反射（P = 0.47）无显著变化。
似乎参与联合训练并补充维生素D可以改善感觉运动神经病变的症状。
