College of Science, University of Shanghai for Science & Technology, Shanghai, PR China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, PR China; State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, People's Republic of China.
College of Science, University of Shanghai for Science & Technology, Shanghai, PR China.
Nanomedicine. 2018 Oct;14(7):2505-2520. doi: 10.1016/j.nano.2016.12.024. Epub 2017 May 26.
The clinical translation potential of mesenchymal stem cells (MSCs) in regenerative medicine has been greatly exploited. With the merits of high surface area to volume ratio, facile control of components, well retained topography, and the capacity to mimic the native extracellular matrix (ECM), nanofibers have received a great deal of attention as bone tissue engineering scaffolds. Electrospinning has been considered as an efficient approach for scale-up fabrication of nanofibrous materials. Electrospun nanofibers are capable of stimulating cell-matrix interaction to form a cell niche, directing cellular behavior, and promoting the MSCs adhesion and proliferation. In this review, we give a comprehensive literature survey on the mechanisms of electrospun nanofibers in supporting the MSCs differentiation. Specifically, the influences of biological and physical osteogenic inductive cues on the MSCs osteogenic differentiation are reviewed. Along with the significant advances in the field, current research challenges and future perspectives are also discussed.
间充质干细胞（MSCs）在再生医学中的临床转化潜力得到了广泛的开发。由于具有高的比表面积与体积比、易于控制成分、良好的形貌保留和模拟天然细胞外基质（ECM）的能力，纳米纤维作为骨组织工程支架受到了极大的关注。静电纺丝被认为是大规模制造纳米纤维材料的有效方法。静电纺纳米纤维能够刺激细胞-基质相互作用，形成细胞龛，指导细胞行为，并促进 MSCs 的黏附和增殖。在这篇综述中，我们对静电纺纳米纤维支持 MSCs 分化的机制进行了全面的文献调查。具体来说，我们综述了生物和物理成骨诱导线索对 MSCs 成骨分化的影响。随着该领域的显著进展，我们还讨论了当前的研究挑战和未来的展望。
