Jones M L, Gibbons P M, Roussel A J, Dominguez B J
Department of Large Animal Clinical Sciences, Texas A&M University College of Veterinary Medicine and Biomedical Sciences, College Station, TX.
J Vet Intern Med. 2017 Jul;31(4):1202-1208. doi: 10.1111/jvim.14743. Epub 2017 May 29.
Knowledge of the mineral composition of the causative urolith is important to develop preventative strategies. Advances in analytic techniques have led to detection of urolith components not previously recognized.
HYPOTHESIS/OBJECTIVES: The objectives of this study were to characterize uroliths in sheep and goats structurally and clinically. We hypothesized that amorphous magnesium calcium phosphate (AMCP) would be a naturally occurring urolith type in sheep and goats.
Forty-nine sheep and goats presenting for obstructive urolithiasis from June 15, 2014 through June 14, 2016 were reviewed along with the demographic data of all small ruminants admitted during that same period.
Medical records were reviewed for demographic and historical data, and 36 uroliths obtained from these cases during diagnostic or therapeutic procedures were analyzed by infrared spectroscopy to determine chemical composition.
AMCP is a naturally occurring urolith type in obstructed male sheep and goats and was the most common urolith type in this study, where it occurred as a majority component with struvite (39% of uroliths) or as a pure component (11%). Pure struvite was found in 1 urolith (2%). Calcium carbonate was the second most frequent urolith with 31% of uroliths being pure calcium carbonate.
This study demonstrates that uroliths, which appear consistent with struvite, could actually be calcium-containing AMCP. Urolith analysis is critical in determining mineral content of uroliths to guide dietary recommendations for prevention.
了解致病性尿路结石的矿物质组成对于制定预防策略很重要。分析技术的进步已导致检测到以前未被识别的尿路结石成分。
假设/目标：本研究的目的是从结构和临床方面对绵羊和山羊的尿路结石进行特征描述。我们假设无定形磷酸镁钙（AMCP）是绵羊和山羊中天然存在的一种尿路结石类型。
回顾了2014年6月15日至2016年6月14日因阻塞性尿路结石前来就诊的49只绵羊和山羊，以及同一时期收治的所有小型反刍动物的人口统计学数据。
查阅病历以获取人口统计学和病史数据，并对在诊断或治疗过程中从这些病例中获得的36块尿路结石进行红外光谱分析以确定化学成分。
AMCP是阻塞性雄性绵羊和山羊中天然存在的一种尿路结石类型，并且是本研究中最常见的尿路结石类型，它以与鸟粪石（占尿路结石的39%）作为主要成分或作为纯成分（11%）出现。在1块尿路结石（2%）中发现了纯鸟粪石。碳酸钙是第二常见的尿路结石，31%的尿路结石是纯碳酸钙。
本研究表明，看似与鸟粪石一致的尿路结石实际上可能是含钙的AMCP。尿路结石分析对于确定尿路结石的矿物质含量以指导预防饮食建议至关重要。
