Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700019. Epub 2017 Jul 18.
Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry-enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism.
Hippuric acid was measured with LC-QTOF-MS metabolite profiling analysis from fasting serum samples at baseline and after an 8-week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5-fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = -0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198).
Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function.
尿马尿酸已被提议作为水果、蔬菜和多酚消耗的生物标志物。我们评估了富含越桔的饮食（BB；高花青素摄入量）和另一种浆果饮食（包括草莓、覆盆子和云莓）（SRC；低花青素摄入量）后血清马尿酸如何变化，以及这些变化如何与胰岛素和葡萄糖代谢相关。
47 名代谢综合征特征的个体在基线时和 8 周干预后使用 LC-QTOF-MS 代谢物谱分析从空腹血清样本中测量马尿酸，这些个体被随机分配到 BB 饮食（n=15）、SRC 饮食（n=20）或对照饮食（n=12）。仅在 BB 组中，空腹血清马尿酸显著增加（3.5 倍，p=0.001），并与空腹血浆葡萄糖浓度变化相关（r=-0.54，p<0.05）和胰岛素分泌（r=0.59，p<0.05）。这些关联在芬兰糖尿病预防研究（n=198）中得到了证实。
食用富含花青素的越桔后，空腹血清马尿酸增加，并且可能通过与更好的血糖控制和β细胞功能相关联，对越桔的有益作用做出贡献。
