Zarei Iman, Eloranta Aino-Maija, Klåvus Anton, Väistö Juuso, Lehtonen Marko, Mikkonen Santtu, Koistinen Ville M, Sallinen Taisa, Haapala Eero A, Lintu Niina, Soininen Sonja, Haikonen Retu, Atalay Mustafa, Schwab Ursula, Auriola Seppo, Kolehmainen Marjukka, Hanhineva Kati, Lakka Timo A
Institute of Public Health and Clinical Nutrition, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
iScience. 2024 Jun 17;27(7):110295. doi: 10.1016/j.isci.2024.110295. eCollection 2024 Jul 19.
Long-term lifestyle interventions in childhood and adolescence can significantly improve cardiometabolic health, but the underlying molecular mechanisms remain poorly understood. To address this knowledge gap, we conducted an 8-year diet and physical activity intervention in a general population of children. The research revealed that the intervention influenced 80 serum metabolites over two years, with 17 metabolites continuing to be affected after eight years. The intervention primarily impacted fatty amides, including palmitic amide, linoleamide, oleamide, and others, as well as unsaturated fatty acids, acylcarnitines, phospholipids, sterols, gut microbiota-derived metabolites, amino acids, and purine metabolites. Particularly noteworthy were the pronounced changes in serum fatty amides. These serum metabolite alterations could represent molecular mechanisms responsible for the observed benefits of long-term lifestyle interventions on cardiometabolic and overall health since childhood. Understanding these metabolic changes may provide valuable insights into the prevention of cardiometabolic and other non-communicable diseases since childhood.
儿童和青少年时期的长期生活方式干预可显著改善心脏代谢健康，但其潜在的分子机制仍知之甚少。为填补这一知识空白，我们对普通儿童群体进行了为期8年的饮食和体育活动干预。研究发现，该干预在两年内影响了80种血清代谢物，8年后仍有17种代谢物受到影响。该干预主要影响脂肪酰胺，包括棕榈酰胺、亚油酰胺、油酰胺等，以及不饱和脂肪酸、酰基肉碱、磷脂、甾醇、肠道微生物群衍生代谢物、氨基酸和嘌呤代谢物。特别值得注意的是血清脂肪酰胺的显著变化。这些血清代谢物的改变可能代表了长期生活方式干预对儿童心脏代谢和整体健康所观察到的益处的分子机制。了解这些代谢变化可能为儿童期心脏代谢疾病和其他非传染性疾病的预防提供有价值的见解。
