补充花青素对血脂水平的影响：一项系统评价和荟萃分析。

Effects of anthocyanin supplementation on blood lipid levels: a systematic review and meta-analysis.

作者信息

Jang Hwan-Hee, Hwang In-Guk, Lee Young-Min

机构信息

Functional Food Division, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, Republic of Korea.

Department of Practical Science Education, Gyeongin National University of Education, Incheon, Republic of Korea.

出版信息

Front Nutr. 2023 Aug 15;10:1207751. doi: 10.3389/fnut.2023.1207751. eCollection 2023.

INTRODUCTION

Dyslipidemia is a major cardiovascular disease risk factor associated with increased mortality. The intake of plant food-derived bioactive compounds is associated with beneficial cardiovascular effects, including decreased blood lipid levels and cardiovascular risk. We aimed to evaluate the effects of anthocyanin intake on blood lipid levels by analyzing relevant randomized controlled trials.

METHODS

We searched the PubMed and Embase databases using the "Patient/Population, Intervention, Comparison, and Outcomes" format to determine whether anthocyanin supplementation intervention affected blood lipid levels compared with placebo supplementation in human participants.

RESULTS

A total of 41 studies with 2,788 participants were included in the meta-analysis. Anthocyanin supplementation significantly reduced triglyceride [standardized mean difference (SMD) = -0.10; 95% confidence interval [CI], -0.18, -0.01) and low-density lipoprotein-cholesterol (SMD = -0.16; 95% CI -0.26, -0.07) levels and increased high-density lipoprotein-cholesterol levels (SMD = 0.42; 95% CI 0.20, 0.65).

DISCUSSION

Anthocyanin supplementation significantly improved blood lipid component levels in the included studies. Larger, well-designed clinical trials are needed to further investigate the effects of anthocyanin intake on blood lipid levels and the safety of anthocyanin supplementation for treating dyslipidemia.

SYSTEMATIC REVIEW REGISTRATION

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021257087, identifier: CRD42021257087.

引言

血脂异常是一种主要的心血管疾病风险因素，与死亡率增加相关。摄入植物性食物来源的生物活性化合物具有有益的心血管效应，包括降低血脂水平和心血管风险。我们旨在通过分析相关随机对照试验来评估花青素摄入对血脂水平的影响。

方法

我们使用“患者/人群、干预措施、对照和结局”格式检索了PubMed和Embase数据库，以确定与安慰剂补充相比，花青素补充干预对人类参与者血脂水平的影响。

结果

荟萃分析共纳入41项研究，涉及2788名参与者。补充花青素显著降低了甘油三酯[标准化均数差（SMD）=-0.10；95%置信区间（CI），-0.18，-0.01]和低密度脂蛋白胆固醇水平（SMD=-0.16；95%CI -0.26，-0.07），并提高了高密度脂蛋白胆固醇水平（SMD=0.42；95%CI 0.20，0.65）。