1例与麻风病相关的皮下暗色丝孢霉病
A Case of Subcutaneous Phaeohyphomycosis Associated with Leprosy.
作者信息
Teixeira Márcia M R, Assunção Claudia B, Lyon Sandra, Gomes Renata R, Junior Hyllo B M, Rocha-Silva Fabiana, de Figueiredo Sônia M, Machado Amanda Sanchez, Teixeira Elen R R, Carneiro Adriana S, Júnior Rogério J M B, Vicente Vânia A, Caligiorne Rachel B
机构信息
Faculdade de Medicina da Universidade Federal de Minas Gerais, MG. Brazil.
Núcleo de Pós-Graduação e Pesquisa da Santa Casa de Belo Horizonte, MG. Brazil.
出版信息
Infect Disord Drug Targets. 2017;17(3):223-226. doi: 10.2174/1871526517666170530124905.
BACKGROUND
Subcutaneous phaeohyphomycosis is an infection caused by melanized fungi and is increasingly reported among immunosuppressive patients. The most commonly cited etiologic agent is Exophiala jeanselmei, followed by Alternaria spp. We present a case of subcutaneous phaeohyphomycosis in a 48-yearold woman, with a history of lepromatous leprosy, using corticosteroid in immunosuppressive doses due to a type 2 repetitive reaction leprosy outbreak.
RESULT AND DISCUSSION
The diagnosis was confirmed by fine-needle aspiration of the secretion, with subsequent direct mycological observations, culture and molecular analysis. The species agent was identified by culture and nucleotide sequences of ribosomal DNA as Exophiala dermatitidis.
背景
皮下暗色丝孢霉病是由黑色素真菌引起的一种感染，在免疫抑制患者中的报道日益增多。最常被提及的病原体是甄氏外瓶霉，其次是链格孢属。我们报告一例48岁女性的皮下暗色丝孢霉病病例，该患者有瘤型麻风病史，因2型麻风反应复发而使用免疫抑制剂量的皮质类固醇。
结果与讨论
通过对分泌物进行细针穿刺抽吸，并随后进行直接真菌学观察、培养和分子分析，确诊了该病。通过培养和核糖体DNA的核苷酸序列鉴定出病原体为皮炎外瓶霉。
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