Zhu Chun-Hui, Xu Dong, Liu Wei, Guo Di, Ning Qin, Chen Guang
Department of Infectious Disease, Children's Hospital of Jiangxi Province, Nanchang, China.
Department of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
IDCases. 2017 May 5;9:21-24. doi: 10.1016/j.idcr.2017.04.017. eCollection 2017.
To define the clinical manifestations and laboratory characteristics of pediatric severe fever with thrombocytopenia syndrome (SFTS) case caused by a novel bunyavirus. we retrospectively analyzed a pediatric case of viral SFTS in a 13 year old successfully managed and confirmed to be due to the novel bunyavirus now referred to as Huaiyangshan virus. A literature review of related cases was performed.Our pediatric case was a 13.3-year-old middle school student no underlying disease. Major clinical features included a fever with chills, headache, and dizziness. The patient's epidemiology showed he had close contact with his grandfather who had a confirmed, novel bunyavirus infection. Symptomatic theraphy were given at admission. The patient's temperature and platelet count returned to normal by days 7 and 10, respectively, and he was discharged from the hospital with an improved condition. A literature search was performed using "severe fever with thrombocytopenia syndrome" and "bunyavirus" as keywords, but few relevant reports were found. Novel bunyavirus infection can be transmitted through close contact. Confirmed cases should be kept in isolation. Clinical manifestations were characterized by aspecific symptoms, such as fever and chills. In some cases, platelet counts may remain normal in the early phase of the disease, and fever may not present throughout the entire illness period. Thus, misdiagnosis is possible. Surveillance and vigorous follow-up should be carried out in children with tick bites or in close contact with an index patient in high-risk areas during peak season.
为明确由新型布尼亚病毒引起的儿童严重发热伴血小板减少综合征（SFTS）病例的临床表现和实验室特征，我们回顾性分析了1例13岁成功治愈的儿童病毒性SFTS病例，该病例经确诊由新型布尼亚病毒（现称为淮阳山病毒）引起。并对相关病例进行了文献综述。我们的儿童病例是一名13.3岁的中学生，无基础疾病。主要临床特征包括发热伴寒战、头痛和头晕。患者的流行病学调查显示，他与确诊感染新型布尼亚病毒的祖父有密切接触。入院时给予对症治疗。患者的体温和血小板计数分别在第7天和第10天恢复正常，病情好转后出院。以“严重发热伴血小板减少综合征”和“布尼亚病毒”为关键词进行文献检索，发现相关报道较少。新型布尼亚病毒感染可通过密切接触传播。确诊病例应隔离治疗。临床表现以发热、寒战等非特异性症状为特征。在某些情况下，疾病早期血小板计数可能正常，且整个病程中可能不出现发热。因此，可能会出现误诊。在高发季节，对被蜱叮咬的儿童或与高危地区的指示病例密切接触的儿童应进行监测和严格随访。
