DeWalt Gloria J, Eldred William D
Department of Biology, Boston University, Boston, Massachusetts.
J Comp Neurol. 2017 Sep 1;525(13):2955-2967. doi: 10.1002/cne.24252. Epub 2017 Jun 20.
Injury from blast exposure is becoming a more prevalent cause of death and disability worldwide. The devastating neurological impairments that result from blasts are significant and lifelong. Progress in the development of effective therapies to treat injury has been slowed by its heterogeneous pathology and the dearth of information regarding the cellular mechanisms involved. Within the last decade, a number of studies have documented visual dysfunction following injury. This brief review examines damage to the visual system in both humans and animal models of blast injury. The in vivo use of the retina as a surrogate to evaluate brain injury following exposure to blast is also highlighted.
爆炸暴露造成的伤害正成为全球范围内死亡和残疾的一个更普遍的原因。爆炸导致的毁灭性神经损伤严重且会伴随终生。由于其病理的异质性以及有关所涉及细胞机制的信息匮乏，有效治疗损伤的疗法开发进展一直较为缓慢。在过去十年中，多项研究记录了爆炸损伤后的视觉功能障碍。这篇简短的综述探讨了爆炸损伤的人类和动物模型中视觉系统的损伤情况。还强调了在体内使用视网膜作为评估爆炸暴露后脑损伤的替代物。
