a Human Nutrition Research Centre, Institute of Cellular Medicine , Newcastle University , Newcastle on Tyne , UK.
b Institute of Cellular Medicine, MoveLab , Newcastle University , Newcastle upon Tyne , UK.
Int J Food Sci Nutr. 2018 Feb;69(1):74-83. doi: 10.1080/09637486.2017.1328666. Epub 2017 May 31.
Dietary nitrate (NO) supplementation has been associated with improved vascular and metabolic health. We conducted a double-blind, cross-over, placebo-controlled RCT to investigate the effects of 7-d consumption of beetroot juice compared with placebo on (1) blood pressure (BP) measured in resting conditions and during exercise, (2) cardiac and peripheral vascular function and (3) biomarkers of inflammation, oxidative stress and endothelial integrity. Twenty non-smoking healthy participants aged 60-75 years and BMI 20.0-29.9 kg/m were recruited. Measurement was conducted before and after each 7-d intervention period. Consumption of NO had no effect on resting systolic and diastolic BP. NO consumption did not improve indexes of central and peripheral cardiac function responses during cardiopulmonary exercise testing. Dietary NO supplementation did not modify biomarkers of inflammation, oxidative stress and endothelial integrity. This study does not support the short-term benefits of dietary NO supplementation on physiological and biochemical markers of vascular health in older healthy adults.
饮食硝酸盐（NO）补充与改善血管和代谢健康有关。我们进行了一项双盲、交叉、安慰剂对照 RCT，以研究 7 天内饮用甜菜根汁与安慰剂相比对（1）静息和运动时血压（BP）的影响，（2）心脏和外周血管功能，以及（3）炎症、氧化应激和内皮完整性的生物标志物的影响。共招募了 20 名年龄在 60-75 岁、BMI 在 20.0-29.9kg/m 之间的不吸烟健康参与者。在每个 7 天干预期前后进行了测量。NO 的摄入对静息收缩压和舒张压没有影响。NO 的摄入并没有改善心肺运动测试期间中心和外周心脏功能反应的指标。饮食 NO 补充并没有改变炎症、氧化应激和内皮完整性的生物标志物。本研究不支持短期饮食 NO 补充对老年健康成年人血管健康的生理和生化标志物的益处。
