Sun Ying, Mensah Fiona K, Azzopardi Peter, Patton George C, Wake Melissa
Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui Province, China;
Centre for Adolescent Health.
Pediatrics. 2017 Jun;139(6). doi: 10.1542/peds.2016-4099.
Early pubertal timing is linked with a range of adverse health outcomes later. Given recent trends of earlier pubertal maturation, there is growing interest in the factors influencing pubertal timing. Socioeconomic disadvantage has been previously linked with reproductive strategies later in life. In this study, we aim to determine the association between cumulative social disadvantages in early life and early puberty in a population-based birth cohort.
Data are from the B (baby) cohort of The Longitudinal Study of Australian Children. Children ( = 5107) were aged 0 to 1 years when recruited in 2004 and 10 to 11 years ( = 3764) at Wave 6 in 2015. Household socioeconomic position (SEP) and neighborhood socioeconomic disadvantage were collected at all 6 waves. Trajectories of disadvantage were identified through latent class models. Early puberty at Wave 6 was assessed from parental reports using an adaptation of the Pubertal Development Scale.
Cumulative exposure to extremely unfavorable household SEP in boys independently predicted a fourfold increase (odds ratio = 4.22, 95% confidence interval 2.27-7.86) in the rate of early puberty. In girls, the increase was twofold (odds ratio = 1.96, 95% confidence interval 1.08-3.56). We found no effect from neighborhood disadvantage once family SEP was taken into account.
Cumulative exposure to household socioeconomic disadvantage in early life predicts earlier pubertal timing in both boys and girls. This may represent 1 mechanism underpinning associations between early life disadvantage and poor health in later life.
青春期提前与一系列后期不良健康结局相关。鉴于近期青春期成熟提前的趋势，人们对影响青春期时间的因素的兴趣日益增加。社会经济劣势此前已与成年后期的生殖策略相关联。在本研究中，我们旨在确定基于人群的出生队列中早期生活累积社会劣势与青春期提前之间的关联。
数据来自澳大利亚儿童纵向研究的B（婴儿）队列。2004年招募时儿童年龄为0至1岁（n = 5107），2015年第6波随访时为10至11岁（n = 3764）。在所有6波随访中收集家庭社会经济地位（SEP）和邻里社会经济劣势信息。通过潜在类别模型确定劣势轨迹。第6波随访时的青春期提前情况通过对父母报告采用青春期发育量表改编版进行评估。
男孩累积暴露于极其不利的家庭SEP独立预测青春期提前发生率增加四倍（优势比 = 4.22，95%置信区间2.27 - 7.86）。女孩的增加为两倍（优势比 = 1.96，95%置信区间1.08 - 3.56）。考虑家庭SEP后，我们未发现邻里劣势有影响。
早期生活中累积暴露于家庭社会经济劣势可预测男孩和女孩青春期提前。这可能是早期生活劣势与后期不良健康之间关联的一种潜在机制。
