• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Radiosensitization of cancer stem cells in glioblastoma by the simultaneous inhibition of parallel DNA damage response pathways.通过同时抑制平行DNA损伤反应途径对胶质母细胞瘤中癌症干细胞的放射增敏作用。
Ann Transl Med. 2017 May;5(Suppl 1):S2. doi: 10.21037/atm.2017.03.39.
2
DNA double strand break repair inhibition as a cause of heat radiosensitization: re-evaluation considering backup pathways of NHEJ.DNA双链断裂修复抑制作为热放射增敏的原因：考虑非同源末端连接备份途径的重新评估
Int J Hyperthermia. 2008 Feb;24(1):17-29. doi: 10.1080/02656730701784782.
3
Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins.靶向MPS1通过调节DNA修复蛋白增强人胶质母细胞瘤的放射敏感性。
Mol Cancer Res. 2015 May;13(5):852-62. doi: 10.1158/1541-7786.MCR-14-0462-T. Epub 2015 Feb 26.
4
HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway.法尼基转移酶抑制剂R115777使多形性胶质母细胞瘤细胞放射增敏的靶点HDJ-2及p53/p21途径的作用
Cancer Res. 2006 Jul 1;66(13):6756-62. doi: 10.1158/0008-5472.CAN-06-0185.
5
Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization.丝裂原活化蛋白激酶（MAPK）和磷脂酰肌醇-3-激酶/雷帕霉素靶蛋白（PI3K/mTOR）信号通路的同时扰动不会导致放射增敏作用增强。
Radiat Oncol. 2015 Oct 24;10:214. doi: 10.1186/s13014-015-0514-5.
6
[Cancer stem cells, cornerstone of radioresistance and perspectives for radiosensitization: glioblastoma as an example].[癌症干细胞：放射抗性的基石与放射增敏的前景——以胶质母细胞瘤为例]
Bull Cancer. 2012 Dec;99(12):1153-60. doi: 10.1684/bdc.2012.1666.
7
Coculture with astrocytes reduces the radiosensitivity of glioblastoma stem-like cells and identifies additional targets for radiosensitization.与星形胶质细胞共培养可降低胶质母细胞瘤干细胞样细胞的放射敏感性，并确定放射增敏的其他靶点。
Cancer Med. 2015 Nov;4(11):1705-16. doi: 10.1002/cam4.510. Epub 2015 Oct 30.
8
Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells.Akt 抑制剂 MK-2206 对胶质母细胞瘤细胞迁移和辐射敏感性的差异影响。
BMC Cancer. 2019 Apr 3;19(1):299. doi: 10.1186/s12885-019-5517-4.
9
Synergistic Effects of Arsenite on Radiosensitization of Glioblastoma Cells.亚砷酸盐对胶质母细胞瘤细胞放射增敏的协同作用。
Anticancer Res. 2017 Aug;37(8):4111-4117. doi: 10.21873/anticanres.11798.
10
Iododeoxyuridine radiosensitization of human glioblastoma cells exposed to acute and chronic gamma irradiation: mechanistic implications and clinical relevance.碘脱氧尿苷对暴露于急性和慢性γ射线照射的人胶质母细胞瘤细胞的放射增敏作用：机制意义和临床相关性。
Cancer J Sci Am. 1995 Jul-Aug;1(2):151-61.

引用本文的文献

1
Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma.赖氨酸特异性组蛋白去甲基化酶 1A（KDM1A/LSD1）抑制减弱了 DNA 双链断裂修复，并增强了替莫唑胺在胶质母细胞瘤中的疗效。
Neuro Oncol. 2023 Jul 6;25(7):1249-1261. doi: 10.1093/neuonc/noad018.
2
Hyperoxygenation as a Therapeutic Supplement for Treatment of Triple Negative Breast Cancer.高氧作为三阴性乳腺癌治疗的辅助疗法
Front Oncol. 2018 Nov 20;8:527. doi: 10.3389/fonc.2018.00527. eCollection 2018.

本文引用的文献

1
Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells.选择性抑制平行的 DNA 损伤反应通路可优化脑胶质瘤干细胞的放射增敏作用。
Cancer Res. 2015 Oct 15;75(20):4416-28. doi: 10.1158/0008-5472.CAN-14-3790. Epub 2015 Aug 17.
2
PARP inhibitors in the management of breast cancer: current data and future prospects.PARP抑制剂在乳腺癌治疗中的应用：当前数据与未来前景
BMC Med. 2015 Aug 13;13:188. doi: 10.1186/s12916-015-0425-1.
3
Genetic and functional diversity of propagating cells in glioblastoma.胶质母细胞瘤中增殖细胞的遗传和功能多样性。
Stem Cell Reports. 2015 Jan 13;4(1):7-15. doi: 10.1016/j.stemcr.2014.11.003. Epub 2014 Dec 18.
4
Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase.通过抑制 ATM 激酶消除胶质母细胞瘤干细胞样细胞中的放射抗性。
Mol Oncol. 2015 Jan;9(1):192-203. doi: 10.1016/j.molonc.2014.08.003. Epub 2014 Aug 24.
5
Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells.对组成型PARP激活进行治疗靶向会损害胶质母细胞瘤起始细胞的干细胞表型和存活。
Cell Death Differ. 2014 Feb;21(2):258-69. doi: 10.1038/cdd.2013.136. Epub 2013 Oct 11.
6
Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide.ATM 和 ATR 对胶质母细胞瘤和恶性黑色素瘤细胞对甲基化抗癌药物替莫唑胺耐药性的贡献。
Mol Cancer Ther. 2013 Nov;12(11):2529-40. doi: 10.1158/1535-7163.MCT-13-0136. Epub 2013 Aug 19.
7
ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.ATM 激酶抑制作用优先增强 p53 突变型脑胶质瘤对电离辐射的敏感性。
Clin Cancer Res. 2013 Jun 15;19(12):3189-200. doi: 10.1158/1078-0432.CCR-12-3408. Epub 2013 Apr 25.
8
A restricted cell population propagates glioblastoma growth after chemotherapy.化疗后，受限制的细胞群体促进胶质母细胞瘤生长。
Nature. 2012 Aug 23;488(7412):522-6. doi: 10.1038/nature11287.
9
Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells.哺乳动物和人类细胞中微核、核质桥和核芽形成的分子机制。
Mutagenesis. 2011 Jan;26(1):125-32. doi: 10.1093/mutage/geq052.
10
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.ATM-Chk2 和 ATR-Chk1 通路在 DNA 损伤信号转导和癌症中的作用。
Adv Cancer Res. 2010;108:73-112. doi: 10.1016/B978-0-12-380888-2.00003-0.

Radiosensitization of cancer stem cells in glioblastoma by the simultaneous inhibition of parallel DNA damage response pathways.

作者信息

Fukumoto Yasunori

机构信息

Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.

出版信息

Ann Transl Med. 2017 May;5(Suppl 1):S2. doi: 10.21037/atm.2017.03.39.

DOI:10.21037/atm.2017.03.39
PMID:28567384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5440309/
Abstract
摘要