Aoyama Norio, Suzuki Jun-Ichi, Kobayashi Naho, Hanatani Tomoya, Ashigaki Norihiko, Yoshida Asuka, Shiheido Yuka, Sato Hiroki, Kumagai Hidetoshi, Ikeda Yuichi, Akazawa Hiroshi, Komuro Issei, Izumi Yuichi, Isobe Mitsuaki
Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Department of Advanced Clinical Science and Therapeutics, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Heart Vessels. 2017 Nov;32(11):1314-1319. doi: 10.1007/s00380-017-1003-6. Epub 2017 May 31.
Peripheral arterial disease (PAD) is a common manifestation of arterial stenosis of the extremity that reduces arterial flow. While patients with periodontitis are at a high risk of PAD, little causal information has been provided to date. To clarify the relationship, we conducted this cross-sectional study. The oral condition of patients with or without PAD, who attended Tokyo Medical and Dental University Hospital, was evaluated. Blood examinations and dental clinical measurements, including number of teeth, probing pocket depth (PPD), bleeding on probing (BOP) and clinical attachment level (CAL) were performed. Chi-square test was performed to compare gender, smoker rate, prevalence of DM, hypertension and dyslipidemia and edentulous rate. Wilcoxon test was used to compare bacterial counts and anti-bacterial antibodies and Student's t test was used to compare the other numerical values. The subjects were patients with (n = 34) or without (n = 956) PAD. We revealed that the PAD patients had more missing teeth (17.5 ± 11.0), a higher rate of edentulism (18%), and higher serum inflammatory factor levels than non-PAD patients (10.9 ± 8.7, 5%, respectively). On the other hand, there was no significant difference between hypertension, dyslipidemia, smoking status, HbA1c, bacterial antibody titers, and bacterial counts between the groups. In conclusion, we clarified that PAD patients had decreased tooth number and worsened oral and periodontal condition with enhanced systemic inflammation.
外周动脉疾病（PAD）是肢体动脉狭窄的常见表现，会减少动脉血流。虽然牙周炎患者患PAD的风险很高，但迄今为止几乎没有提供因果关系信息。为了阐明这种关系，我们进行了这项横断面研究。对就诊于东京医科齿科大学医院的有或无PAD患者的口腔状况进行了评估。进行了血液检查和牙科临床测量，包括牙齿数量、探诊深度（PPD）、探诊出血（BOP）和临床附着水平（CAL）。采用卡方检验比较性别、吸烟率、糖尿病、高血压和血脂异常的患病率以及无牙率。采用Wilcoxon检验比较细菌计数和抗菌抗体，采用Student's t检验比较其他数值。研究对象为患有（n = 34）或未患有（n = 956）PAD的患者。我们发现，与非PAD患者相比，PAD患者的缺牙更多（17.5 ± 11.0），无牙率更高（18%），血清炎症因子水平也更高（分别为10.9 ± 8.7和5%）。另一方面，两组之间在高血压、血脂异常、吸烟状况、糖化血红蛋白、细菌抗体滴度和细菌计数方面没有显著差异。总之，我们阐明了PAD患者牙齿数量减少，口腔和牙周状况恶化，全身炎症增强。
