Wang Yang, Wang Weihao, Peng Weijun, Liu Weiping, Cai Weijun, Xia Zian, Zhang Honggeng, Xing And Zhihua
Institute of Integrated Medicine, Xiangya Hospital, Central South University, Changsha 410008, P.R. China.
Department of Integrated Chinese and Western Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, P.R. China.
Afr J Tradit Complement Altern Med. 2017 Jan 13;14(2):65-74. doi: 10.21010/ajtcam.v14i2.8. eCollection 2017.
Bao-Xin-Tang (BXT) is a traditional Chinese medicinal formula used for the treatment of coronary heart disease and known to have favorable therapeutic benefits. The current study was designed to determine whether BXT has a cardioprotective role for acute myocardial infarction. The underlying mechanisms were also explored.
The Sprague-Dawley rat model of acute myocardial infarction was established by occluding the left anterior descending branch of the coronary artery. After a 3-h ischemic period, we determined the myocardial infarction size, inflammatory components, and antioxidant activities.
The data showed that BXT could reduce the infarction size and lower the levels of C-reactive protein, interleukin-6, and myeloperoxidase, and increase the activities of superoxide dismutase and the anti-inflammatory cytokine, interleukin-10. These results indicate that administration of BXT, following acute myocardial infarction, could reduce infarct size.
The effects of BXT may be related to its anti-inflammatory and anti-oxidative properties.
保心汤（BXT）是一种用于治疗冠心病的中药方剂，已知具有良好的治疗效果。本研究旨在确定BXT对急性心肌梗死是否具有心脏保护作用。同时也探讨了其潜在机制。
通过结扎冠状动脉左前降支建立急性心肌梗死的Sprague-Dawley大鼠模型。在3小时缺血期后，我们测定了心肌梗死面积、炎症成分和抗氧化活性。
数据显示，BXT可减小梗死面积，降低C反应蛋白、白细胞介素-6和髓过氧化物酶水平，并增加超氧化物歧化酶和抗炎细胞因子白细胞介素-10的活性。这些结果表明，急性心肌梗死后给予BXT可减小梗死面积。
BXT的作用可能与其抗炎和抗氧化特性有关。
