Vichy Laboratoires, Asnières sur Seine, France.
Department of Dermatology, Hospital Sur, Madrid, Spain.
J Eur Acad Dermatol Venereol. 2017 Oct;31(10):1727-1731. doi: 10.1111/jdv.14379. Epub 2017 Jul 7.
Acne in adult women is an increasing reason for dermatological consultations.
The aim of this study was to assess in adult women with mild acne the efficacy and tolerance of a daily adjunctive application of a skincare (Normaderm , Laboratoires Vichy, France) to a fixed combination of adapalene/benzoyl peroxide daily or every other evening and a standard emollient.
Subjects were randomized to receive the fixed combination applied either every evening or every other evening and a daily application of the standard emollient and the test care or a once daily application of the fixed combination and the standard emollient alone. Clinical evaluations at Day 0, Day 45 and Day 90 included the count of acne lesions, assessment of clinical improvement and local tolerance. The quantitative lipid profile of the stratum corneum of the forehead was also determined.
After 90 days of application, acne had improved in all 299 subjects with a statistically significant difference in favour of the test care regimens (P < 0.05). Moreover, skin quality, subject satisfaction, skin discomfort and sebum composition were in favour of these regimens.
In conclusion, the tested skincare combined with a fixed adapalene and benzoyl peroxide combination provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne.
成年女性痤疮是皮肤科就诊的一个日益常见的原因。
本研究旨在评估轻度痤疮成年女性中，每日使用护肤品（法国 VichyLaboratoires 的 Normaderm）辅助治疗，联合每日或隔日使用固定剂量的阿达帕林/过氧化苯甲酰和标准保湿剂，对改善痤疮和耐受情况的疗效。
将受试者随机分为两组，一组接受每晚使用固定剂量联合每日使用标准保湿剂和测试护肤品，另一组则每日使用固定剂量联合每日使用标准保湿剂。在第 0、45 和 90 天进行临床评估，包括痤疮皮损计数、临床改善评估和局部耐受性评估。还测定了额部角质层的定量脂质谱。
在 299 例接受治疗的患者中，所有患者的痤疮在 90 天后均有改善，其中使用测试护肤品的治疗方案具有统计学意义的显著改善（P < 0.05）。此外，皮肤质量、患者满意度、皮肤不适和皮脂组成均有利于这些方案。
总之，经测试的护肤品联合固定剂量的阿达帕林和过氧化苯甲酰组合，在轻度痤疮的成年女性中提供了显著的辅助疗效和局部耐受性获益。
