Khajavi Rad Abolfazl, Mohebbati Reza, Hosseinian Sara
Pharmacological Research Center of Medicinal Plants, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Kidney Dis. 2017 May;11(3):169-179.
Drug-induced nephrotoxicity is one of the most common causes of acute kidney injury. There are various agents that exert nephrotoxic effects through different pathogenic mechanisms. Aminoglycoside antibiotics, chemotherapeutic agents, radiocontrast media, and nonsteroidal anti-inflammatory drugs are among common nephrotoxic agents. In recent years, natural compounds are being increasingly used in the treatment of kidney diseases. Given many reports available on the curative effects of a variety of medicinal plants against drug-associated nephrotoxicity, we aimed to review the protective effects of medicinal plants on certain nephrotoxic drugs.
药物性肾毒性是急性肾损伤最常见的原因之一。有多种药物可通过不同的致病机制产生肾毒性作用。氨基糖苷类抗生素、化疗药物、放射性造影剂和非甾体类抗炎药是常见的肾毒性药物。近年来，天然化合物越来越多地用于治疗肾脏疾病。鉴于有许多关于各种药用植物对药物相关性肾毒性疗效的报道，我们旨在综述药用植物对某些肾毒性药物的保护作用。
