Zhou Yuwei, Hu Ke, Guo Zhaobin, Fang Kun, Wang Xing, Yang Fang, Gu Ning
State Key Laboratory of Bioelectronics and Jiangsu Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China.
Key Laboratory of Clinical Engineering, Nanjing Medical University, Nanjing 211166, China.
Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:349-353. doi: 10.1016/j.msec.2017.04.100. Epub 2017 Apr 17.
In this study, composite antibacterial microcapsules combining of two antibacterial agents: chlorhexidine acetate and silver nanoparticle were prepared. The chlorhexidine acetate was encapsulated inside of the microcapsules and nano-sized silver particles were modified on the surface of microcapsules by electrostatic adsorption methods. Results show that this method decreases the silver usage dramatically, and promises a sustained antibacterial effect >30days. These microcapsules can also be modified on the surface of polymer films easily, which demonstrated the potential in functionalizing the implanted materials with antibacterial property.
在本研究中，制备了一种复合抗菌微胶囊，它结合了两种抗菌剂：醋酸氯己定和银纳米颗粒。醋酸氯己定被包裹在微胶囊内部，纳米级银颗粒通过静电吸附法修饰在微胶囊表面。结果表明，该方法显著降低了银的用量，并保证了超过30天的持续抗菌效果。这些微胶囊还可以很容易地修饰在聚合物薄膜表面，这表明了其在赋予植入材料抗菌性能方面的潜力。
