Dean James, Kolsum Umme, Hitchen Paul, Gupta Vandana, Singh Dave
Medicines Evaluation Unit, Manchester.
Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.
Int J Chron Obstruct Pulmon Dis. 2017 May 22;12:1503-1506. doi: 10.2147/COPD.S137865. eCollection 2017.
We have used impulse oscillometry to identify COPD patients with tidal expiratory flow limitation (EFL), which is a measurement related to small airway disease. We report that 37.4% of COPD patients had EFL; these patients had multiple clinical characteristics of more severe disease including lower forced expiratory volume in 1 second values, greater hyperinflation, reduced exercise performance, and increased small airway impairment. We highlight that EFL can be used to identify a subgroup of COPD patients with distinct characteristics associated with small airway disease.
我们使用脉冲振荡法来识别患有潮气呼气流量受限（EFL）的慢性阻塞性肺疾病（COPD）患者，这是一种与小气道疾病相关的测量方法。我们报告称，37.4%的COPD患者存在EFL；这些患者具有多种更严重疾病的临床特征，包括1秒用力呼气量值较低、肺过度充气更严重、运动能力下降以及小气道损伤增加。我们强调，EFL可用于识别一组具有与小气道疾病相关独特特征的COPD患者亚组。
