Beken Burçin, Can Ceren, Örencik Aysegül, Can Nuray, Yazıcıoğlu Mehtap
Department of Pediatric Allergy and Immunology, Trakya University Medical School, Edirne, Turkey.
Department of Pediatrics, Trakya University Medical School, Edirne, Turkey.
Oxf Med Case Reports. 2017 Jun 1;2017(6):omx028. doi: 10.1093/omcr/omx028. eCollection 2017 Jun.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are two rare but life-threatening diseases characterized by detachment of epidermis, bullous skin lesions and mucous membrane erosions. Anti-epileptic drugs are highly suspected to be the causative agents. Although carbamazepine (CBZ) is the most associated anti-epileptic drug, oxcarbazepine (OXC), which is a monohydrated derivative of CBZ, is proposed to be safer because of the different metabolism of the two drugs. Herein, we report a case of SJS induced by oxcarbazepine. A 6-year-old boy with benign rolandic epilepsy, admitted to our hospital with generalized maculopapular rash after starting oxcarbazepine. The diagnosis of SJS was made with cytotoxic skin lesions and mucous membrane involvement. After discontinuing of the drug and topical corticosteroid initiation, the lesions were improved. We report this case to attract attention to the serious side effect of this anti-epileptic drug.
史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死松解症是两种罕见但危及生命的疾病，其特征为表皮剥脱、水疱性皮肤损害和黏膜糜烂。抗癫痫药物被高度怀疑为致病因素。尽管卡马西平（CBZ）是最常相关的抗癫痫药物，但奥卡西平（OXC）作为CBZ的一水合物衍生物，由于两种药物代谢不同，被认为更安全。在此，我们报告一例由奥卡西平诱发的SJS病例。一名6岁患有良性罗兰多癫痫的男孩，在开始服用奥卡西平后因全身性斑丘疹皮疹入住我院。根据细胞毒性皮肤损害和黏膜受累确诊为SJS。停药并开始局部使用皮质类固醇后，皮损有所改善。我们报告此病例以引起对这种抗癫痫药物严重副作用的关注。
