骨髓抽吸浓缩物采集与处理技术
Bone Marrow Aspirate Concentrate Harvesting and Processing Technique.
作者信息
Chahla Jorge, Mannava Sandeep, Cinque Mark E, Geeslin Andrew G, Codina David, LaPrade Robert F
机构信息
Steadman Philippon Research Institute, Vail, Colorado, U.S.A.
The Steadman Clinic, Vail, Colorado, U.S.A.
出版信息
Arthrosc Tech. 2017 Apr 10;6(2):e441-e445. doi: 10.1016/j.eats.2016.10.024. eCollection 2017 Apr.
Abstract
Bone marrow obtained by iliac crest aspiration is a common source for harvesting mesenchymal stem cells, other progenitor cells, and associated cytokine/growth factors. Recent studies have reported good to excellent outcomes with the use of bone marrow aspirate concentrate (BMAC) for pain relief in the treatment of focal chondral lesions and osteoarthritis of the knee. However, the harvesting and processing technique are crucial to achieve satisfactory results. Several studies have examined outcomes after BMAC injection, with encouraging results, but there is a lack of consensus in terms of the frequency of injection, the amount of BMAC that is injected, and the timing of BMAC injections. The purpose of this Technical Note was to describe a standardized bone marrow aspiration harvesting technique and processing method.
摘要
通过髂嵴穿刺获得的骨髓是采集间充质干细胞、其他祖细胞以及相关细胞因子/生长因子的常见来源。最近的研究报告称，使用骨髓抽吸浓缩物（BMAC）治疗膝关节局灶性软骨损伤和骨关节炎以缓解疼痛取得了良好至优异的效果。然而，采集和处理技术对于取得满意的结果至关重要。多项研究检查了BMAC注射后的效果，结果令人鼓舞，但在注射频率、注射的BMAC量以及BMAC注射时机方面缺乏共识。本技术说明的目的是描述一种标准化的骨髓穿刺采集技术和处理方法。
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