Indrawati Lili, Ascobat Purwantyastuti, Bela Budiman, Abdullah Murdani, Surono Ingrid S
Department of Pharmacotherapy, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia. Email:
Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Indonesia.
Asia Pac J Clin Nutr. 2017;26(4):606-612. doi: 10.6133/apjcn.062016.02.
Annona muricata leaf infusion has traditionally been consumed to maintain health, but is now considered for use in treating cancer patients. The objective of this study was to elucidate the effects of A. muricata leaf extract in humans and human cell lines.
Thirty outpatients with colorectal cancer who had undergone primary tumor resection were enrolled in a randomized double-blind placebo- controlled pre-post-trial. They were divided into two groups: those who ingested A. muricata leaf extract (n=14) and those who ingested a placebo (n=14) daily for 8 weeks. Twenty-eight subjects completed the trial; they were equally distributed between the two groups. Serum from patients of both groups was compared for cytotoxicity against colorectal cancer cell lines. The nutritional status of patients was monitored throughout the study.
Ex vivo and clinical studies showed higher cytotoxicity in the supplemented group compared with the placebo group. Further research is required to investigate the long-term effect of A.muricata leaf extract, particularly on parameters directly related to cytotoxic activity toward colorectal cancer cells and nutrition status.
传统上人们饮用刺果番荔枝叶浸剂来维持健康，现在它被考虑用于治疗癌症患者。本研究的目的是阐明刺果番荔枝叶提取物对人体和人类细胞系的影响。
30例接受原发性肿瘤切除的结直肠癌门诊患者被纳入一项随机双盲安慰剂对照的前后试验。他们被分为两组：每天摄入刺果番荔枝叶提取物的患者（n = 14）和每天摄入安慰剂的患者（n = 14），持续8周。28名受试者完成了试验；他们在两组中平均分布。比较两组患者血清对结直肠癌细胞系的细胞毒性。在整个研究过程中监测患者的营养状况。
体外和临床研究表明，与安慰剂组相比，补充组具有更高的细胞毒性。需要进一步研究来调查刺果番荔枝叶提取物的长期影响，特别是对与针对结直肠癌细胞的细胞毒性活性和营养状况直接相关的参数的影响。
