Dabbousy Ranin, Rima Mohamad, Roufayel Rabih, Rahal Mohamad, Legros Christian, Sabatier Jean-Marc, Fajloun Ziad
Laboratory of Applied Biotechnology (LBA3B), Department of Cell Culture, Azm Center for Research in Biotechnology and Its Applications, EDST, Lebanese University, Tripoli 1300, Lebanon.
Department of Natural Sciences, Lebanese American University, Byblos P.O. Box 36, Lebanon.
Pharmaceuticals (Basel). 2024 Sep 30;17(10):1307. doi: 10.3390/ph17101307.
Drug development from medicinal plants constitutes an important strategy for finding natural anticancer therapies. While several plant secondary metabolites with potential antitumor activities have been identified, well-defined mechanisms of action remained uncovered. In fact, studies of medicinal plants have often focused on the genome, transcriptome, and proteome, dismissing the relevance of the metabolome for discovering effective plant-based drugs. Metabolomics has gained huge interest in cancer research as it facilitates the identification of potential anticancer metabolites and uncovers the metabolomic alterations that occur in cancer cells in response to treatment. This holds great promise for investigating the mode of action of target metabolites. Although metabolomics has made significant contributions to drug discovery, research in this area is still ongoing. In this review, we emphasize the significance of plant metabolomics in anticancer research, which continues to be a potential technique for the development of anticancer drugs in spite of all the challenges encountered. As well, we provide insights into the essential elements required for performing effective metabolomics analyses.
从药用植物中开发药物是寻找天然抗癌疗法的一项重要策略。虽然已经鉴定出几种具有潜在抗肿瘤活性的植物次生代谢产物，但其明确的作用机制仍未被发现。事实上，对药用植物的研究往往集中在基因组、转录组和蛋白质组上，而忽略了代谢组在发现有效的植物源药物方面的相关性。代谢组学在癌症研究中引起了极大的兴趣，因为它有助于识别潜在的抗癌代谢物，并揭示癌细胞在治疗后发生的代谢组学变化。这为研究目标代谢物的作用模式带来了巨大希望。尽管代谢组学在药物发现方面做出了重大贡献，但该领域的研究仍在进行中。在这篇综述中，我们强调了植物代谢组学在抗癌研究中的重要性，尽管面临诸多挑战，但它仍然是开发抗癌药物的一项潜在技术。此外，我们还深入探讨了进行有效代谢组学分析所需的关键要素。
