[Pharmacokinetics of fenazepam and its metabolite 3-oxyfenazepam in animals of different species and in man].

It has been established that phenazepam is rapidly absorbed from the gastrointestinal tract of animals and man. The maximal concentrations of the unchanged drugs are reached 1, 0.5, 2 and 4 hours in rats, dogs, cats and man, respectively. The half-life of phenazepam in animal and human blood decreases in the following order: man greater than cat greater than dog greater than rat. The metabolite 3 + hydroxyphenazepam was identified in appreciable amounts in cat and rat blood.