Zhang Liming, Lu Zhuoxuan, Bai Yingying, Wang Ting, Wang Zhifei, Chen Juan, Ding Yin, Yang Fei, Xiao Zhongdang, Ju Shenghong, Zhu Junjie, He Nongyue
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, P. R. China.
J Mater Chem B. 2013 Mar 7;1(9):1289-1295. doi: 10.1039/c2tb00380e. Epub 2013 Jan 22.
A novel approach of using denatured bovine serum albumin (dBSA) to modify hydrophobic nanocrystals is reported. The dBSA layer outside of nanocrystals can adsorb water insoluble drugs excellently via hydrophobic interactions. Further PEGylation of the engineered nanocrystals greatly improves their aqueous stability. PEGylated dBSA modified upconversion nanoparticles, as a model for construction of integrating imaging and drug delivery platform, were also studied. The results demonstrated the modified upconversion nanoparticles not only maintain their unique up-conversion luminescence characters but also exhibit higher drug loading ability. Thus, such novel PEGylated dBSA modification approach expands the range of biological applications of inorganic nanocrystals.
报道了一种使用变性牛血清白蛋白（dBSA）修饰疏水纳米晶体的新方法。纳米晶体外部的dBSA层可以通过疏水相互作用出色地吸附水不溶性药物。对工程化纳米晶体进一步进行聚乙二醇化修饰可大大提高其在水中的稳定性。还研究了聚乙二醇化dBSA修饰的上转换纳米颗粒，作为构建集成成像和药物递送平台的模型。结果表明，修饰后的上转换纳米颗粒不仅保持了其独特的上转换发光特性，而且还表现出更高的载药能力。因此，这种新型的聚乙二醇化dBSA修饰方法扩展了无机纳米晶体的生物应用范围。
