延长健康寿命的治疗方法进展：来自斯克里普斯衰老生物学研讨会的观点
Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2 Scripps Symposium on the Biology of Aging.
作者信息
Robbins Paul D, Niedernhofer Laura J
机构信息
Department of Molecular Medicine and the Center on Aging, The Scripps Research Institute, Jupiter, FL, 33458, USA.
出版信息
Aging Cell. 2017 Aug;16(4):610-614. doi: 10.1111/acel.12620. Epub 2017 Jun 6.
Abstract
The 2 Scripps Florida Symposium on The Biology of Aging entitled 'Advances in Therapeutic Approaches to Extend Healthspan' was held on January 22 -25 , 2017 at The Scripps Research Institute in Jupiter, Florida. The meeting highlighted a variety of therapeutic approaches in animal models of aging that either are or soon will be in clinic trials. For example, drugs targeting senescent cells, metformin, rapalogs, NAD precursors, young plasma, mitochondrial-targeted free radical scavengers, stem cells, and stem cell factors all have shown significant preclinical efficacy. This perspective, based on presentations and discussions at the symposium, outlines the current and future state of development of therapeutic approaches to extend human healthspan.
摘要
2017年1月22日至25日，两场以“延长健康寿命治疗方法的进展”为主题的斯克里普斯佛罗里达衰老生物学研讨会在佛罗里达州朱庇特市的斯克里普斯研究所举行。会议重点介绍了衰老动物模型中的多种治疗方法，这些方法要么正在进行临床试验，要么即将进入临床试验。例如，靶向衰老细胞的药物、二甲双胍、雷帕霉素类似物、NAD前体、年轻血浆、线粒体靶向自由基清除剂、干细胞和干细胞因子均已显示出显著的临床前疗效。基于研讨会上的报告和讨论，本观点概述了延长人类健康寿命治疗方法的当前和未来发展状况。
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