Bekara Amina, Amazouz Ali, Douma Tahir Benyamina
Laboratory of Natural BioResources, University of Hassiba Benbouali, Chlef, Algeria.
Basic Clin Neurosci. 2020 Jan-Feb;11(1):91-98. doi: 10.32598/bcn.11.1.3. Epub 2020 Jan 1.
The present study aimed to investigate the antidepressant effect of Verbena (V.) officinalis L. aqueous extract in adult female rats.
The present study evaluated the antidepressant effect of V. officinalis L. aqueous (V AE) extract in female rats using the Forced-Swimming Test (FST), Light-Dark Box (LDB) test, and Open Field Test (OFT). The level of glycemia and histological analysis were also studied. The VAE [200 mg/kg Parenterally (PO)] was administered orally for 7 successive days in the separate groups of rats.
The oral administration of V. officinalis L. aqueous extract significantly decreased (P< 0.01) the immobility time in the FST, increased the time spent in the light area (LDB), and the number of entry into the central squares (OFT). Thus, the extract at a dose of 200 mg/kg significantly decreased the glycemia level (P<0.05) and suggested no harmful effect on brain histology.
Verbena officinalis L. aqueous extract at a dose of 200 mg/kg could have an anti-depressant effect in adult rats.
本研究旨在探讨马鞭草水提取物对成年雌性大鼠的抗抑郁作用。
本研究采用强迫游泳试验（FST）、明暗箱试验（LDB）和旷场试验（OFT）评估马鞭草水提取物（V AE）对雌性大鼠的抗抑郁作用。同时还研究了血糖水平和组织学分析。将VAE[200mg/kg，经口（PO）]连续7天口服给予不同组别的大鼠。
口服马鞭草水提取物显著降低（P<0.01）FST中的不动时间，增加在明区的停留时间（LDB）以及进入中央方格的次数（OFT）。因此，200mg/kg剂量的提取物显著降低血糖水平（P<0.05），且对脑组织学无有害影响。
200mg/kg剂量的马鞭草水提取物对成年大鼠可能具有抗抑郁作用。
