Kerman Neuroscience Research Center, Department of Toxicology, Kerman University of Medical Sciences, School of Pharmacy, Kerman, Iran.
J Ethnopharmacol. 2012 Mar 27;140(2):447-51. doi: 10.1016/j.jep.2012.01.024. Epub 2012 Jan 23.
Bunium persicum is an endemic plant to Iran which its seeds have a long history of medicinal uses.
This work aimed to study the anticonvulsant effect of the essential oil and methanolic extract of the plant.
The essential oil and methanolic extract of the plant were studied against pentylenetetrazole (PTZ) and maximal electroshock (MES) induced convulsions in mice in different doses. The neurotoxicity of the essential oil and methanolic extract was investigated using rotarod method.
The essential oil and methanolic extract prolonged the onset of clonic and tonic seizures in PTZ. The tonic seizures were prevented by essential oil in both methods at dose of 1mL/kg and higher doses. The methanolic extract inhibited PTZ-convulsions at dose 3g/kg and was ineffective against MES induced convulsion.
The essential oil of the plant might be useful to control absence and grand mal seizures at dose 1mL/kg. This activity might be due to its content of monoterpenes.
Bunium persicum 是伊朗特有的植物，其种子在医学用途上有着悠久的历史。
本研究旨在研究该植物的精油和甲醇提取物的抗惊厥作用。
以戊四氮（PTZ）和最大电休克（MES）诱导的惊厥为模型，在不同剂量下研究该植物的精油和甲醇提取物的作用。采用旋转棒法研究精油和甲醇提取物的神经毒性。
精油和甲醇提取物可延长 PTZ 引起的阵挛性和强直性惊厥的发作潜伏期。在这两种方法中，精油在 1ml/kg 及更高剂量下可预防强直性惊厥。甲醇提取物在 3g/kg 剂量下可抑制 PTZ 引起的惊厥，但对 MES 诱导的惊厥无效。
该植物的精油在 1ml/kg 剂量下可能对控制失神性和大发作性癫痫有效。这种活性可能与其单萜类成分有关。
