Behzadi Shahed, Serpooshan Vahid, Tao Wei, Hamaly Majd A, Alkawareek Mahmoud Y, Dreaden Erik C, Brown Dennis, Alkilany Alaaldin M, Farokhzad Omid C, Mahmoudi Morteza
Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Chem Soc Rev. 2017 Jul 17;46(14):4218-4244. doi: 10.1039/c6cs00636a.
Nanoscale materials are increasingly found in consumer goods, electronics, and pharmaceuticals. While these particles interact with the body in myriad ways, their beneficial and/or deleterious effects ultimately arise from interactions at the cellular and subcellular level. Nanoparticles (NPs) can modulate cell fate, induce or prevent mutations, initiate cell-cell communication, and modulate cell structure in a manner dictated largely by phenomena at the nano-bio interface. Recent advances in chemical synthesis have yielded new nanoscale materials with precisely defined biochemical features, and emerging analytical techniques have shed light on nuanced and context-dependent nano-bio interactions within cells. In this review, we provide an objective and comprehensive account of our current understanding of the cellular uptake of NPs and the underlying parameters controlling the nano-cellular interactions, along with the available analytical techniques to follow and track these processes.
纳米级材料在消费品、电子产品和药品中越来越常见。虽然这些颗粒与人体有多种相互作用方式，但其有益和/或有害影响最终源于细胞和亚细胞水平的相互作用。纳米颗粒（NPs）可以调节细胞命运、诱导或预防突变、启动细胞间通讯，并以很大程度上由纳米-生物界面现象决定的方式调节细胞结构。化学合成的最新进展产生了具有精确界定生化特征的新型纳米级材料，新兴分析技术也揭示了细胞内细微且依赖于环境的纳米-生物相互作用。在本综述中，我们客观全面地阐述了我们目前对纳米颗粒细胞摄取的理解以及控制纳米-细胞相互作用的潜在参数，同时介绍了用于跟踪和监测这些过程的现有分析技术。
