来自无刺散沫花的具有抑制一氧化氮生成活性的新型苯类衍生物及其他成分。
New Benzenoid Derivatives and Other Constituents from Lawsonia inermis with Inhibitory Activity against NO Production.
作者信息
Yang Chang-Syun, Chen Jih-Jung, Huang Hui-Chi, Huang Guan-Jhong, Wang Sheng-Yang, Sung Ping-Jyun, Cheng Ming-Jen, Wu Ming-Der, Kuo Yueh-Hsiung
机构信息
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan.
Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 112, Taiwan.
出版信息
Molecules. 2017 Jun 5;22(6):936. doi: 10.3390/molecules22060936.
Three new benzenoid derivatives, lawsoinermone (), inermidioic acid (), and inermic acid () have been isolated from the aerial part of , together with 11 known compounds (-). The structures of three new compounds were determined through spectroscopic and MS analyses. Compounds , -, and were evaluated for inhibition of nitric oxide production in LPS-stimulated product of nitrite in RAW 264.7 cells with IC values of 6.12, 16.43, 18.98, 9.30, 9.30 and 14.90 μg/mL, respectively.
从[植物名称]地上部分分离出三种新的苯类衍生物，即罗索因莫内（）、内米二酸（）和内米酸（），以及11种已知化合物（-）。通过光谱和质谱分析确定了三种新化合物的结构。对化合物、-、和进行了评估，以检测其对RAW 264.7细胞中脂多糖刺激产生亚硝酸盐的一氧化氮生成的抑制作用，其IC值分别为6.12、16.43、18.98、9.30、9.30和14.90μg/mL。
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