Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Department of Pharmacology &Toxicology, Faculty of pharmacy, Cairo University, 11562, Cairo, Egypt.
Sci Rep. 2017 Jun 6;7(1):2902. doi: 10.1038/s41598-017-02961-0.
Gingerol is a major dietary compound that occurs in several plants belonging to the Zingiberaceae family. In the current study, the protective effect of gingerol on STZ-induced sporadic Alzheimer's disease (SAD) was determined. Gingerol was isolated from the seeds of Aframomum melegueta K. Schum and tested at doses of 10 and 20 mg/kgbwt for its possible effect on the SAD model in mice, using celecoxib (30 mg/kg bwt) as a reference standard. The curative effects of gingerol were assessed through measurement of β-amyloid (Aβ-42), α-, β- secretases, APH1a and COX-2 levels. In addition, improvement in the cognitive deficit in mice after treatment was confirmed using the water maze and Y-maze with intra-maze cues. Gingerol improved the cognitive and behavioral impairment and AD-like pathology in streptozotocin model mice. These beneficial effects occurred with an increase in α-secretase activity and a decrease in cerebral Aβ-42, β- secretase, APH1a activity and COX-2-linked neuro-inflammation.
姜辣素是几种姜科植物中存在的一种主要膳食化合物。在本研究中，确定了姜辣素对 STZ 诱导的散发性阿尔茨海默病（SAD）的保护作用。姜辣素从 Aframomum melegueta K. Schum 的种子中分离出来，并以 10 和 20mg/kgbwt 的剂量进行测试，以评估其对 SAD 模型小鼠的可能作用，以塞来昔布（30mg/kg bwt）作为参考标准。通过测量β-淀粉样蛋白（Aβ-42）、α-、β-分泌酶、APH1a 和 COX-2 水平来评估姜辣素的疗效。此外，还通过水迷宫和带有室内线索的 Y 迷宫确认了治疗后小鼠认知缺陷的改善。姜辣素改善了链脲佐菌素模型小鼠的认知和行为障碍以及 AD 样病理。这些有益作用与 α-分泌酶活性的增加以及大脑 Aβ-42、β-分泌酶、APH1a 活性和 COX-2 相关的神经炎症的减少有关。
