Gatti P J, Massari V J
Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059.
Neurosci Lett. 1990 Jan 22;108(3):284-8. doi: 10.1016/0304-3940(90)90655-s.
The neuronal stimulant L-glutamic acid (GA) was applied to the ventral medullary surface and diastolic arterial blood pressure (DBP), heart rate (HR), renal and femoral arterial blood flow were measured in the chloralose-anesthetized cat. GA (1.0 M) increased DAP by 27 +/- 6.6 mmHg (P less than 0.05, n = 6), but heart rate was not affected (P greater than 0.05). Renal arterial resistance (RR) increased by 15 +/- 5.8% (P less than 0.05) and femoral resistance (FR) increased by 46 +/- 10% (P less than 0.05). The difference in the change in RR and FR was statistically significant (P less than 0.05). These effects were dose-dependent and could be blocked by prior intravenous administration of the alpha-blocker prazosin. These data indicate that neurons in the intermediate area of the ventromedullary surface may have a greater control over femoral flow than renal flow.
将神经元兴奋剂L-谷氨酸（GA）应用于氯醛糖麻醉猫的延髓腹侧面，并测量舒张期动脉血压（DBP）、心率（HR）、肾动脉和股动脉血流量。GA（1.0 M）使舒张压升高27±6.6 mmHg（P<0.05，n = 6），但心率未受影响（P>0.05）。肾动脉阻力（RR）增加15±5.8%（P<0.05），股动脉阻力（FR）增加46±10%（P<0.05）。RR和FR变化的差异具有统计学意义（P<0.05）。这些效应呈剂量依赖性，并且可被预先静脉注射α受体阻滞剂哌唑嗪所阻断。这些数据表明，延髓腹侧面中间区域的神经元对股动脉血流的控制可能比对肾动脉血流的控制更强。
