Catalani Elisabetta, De Palma Clara, Perrotta Cristiana, Cervia Davide
Department for Innovation in Biological, Agro-Food and Forest Systems (DIBAF), Università degli Studi della Tuscia, Viterbo, Italy.
Unit of Clinical Pharmacology, University Hospital "Luigi Sacco"-ASST Fatebenefratelli Sacco, Milano, Italy.
Biomed Res Int. 2017;2017:5856071. doi: 10.1155/2017/5856071. Epub 2017 May 16.
Neuropeptides drive a wide diversity of biological actions and mediate multiple regulatory functions involving all organ systems. They modulate intercellular signalling in the central and peripheral nervous systems as well as the cross talk among nervous and endocrine systems. Indeed, neuropeptides can function as peptide hormones regulating physiological homeostasis (e.g., cognition, blood pressure, feeding behaviour, water balance, glucose metabolism, pain, and response to stress), neuroprotection, and immunomodulation. We aim here to describe the recent advances on the role exerted by neuropeptides in the control of autophagy and its molecular mechanisms since increasing evidence indicates that dysregulation of autophagic process is related to different pathological conditions, including neurodegeneration, metabolic disorders, and cancer.
神经肽驱动着广泛多样的生物学作用，并介导涉及所有器官系统的多种调节功能。它们调节中枢和外周神经系统中的细胞间信号传导以及神经和内分泌系统之间的相互作用。实际上，神经肽可以作为调节生理稳态（如认知、血压、摄食行为、水平衡、葡萄糖代谢、疼痛和应激反应）、神经保护和免疫调节的肽类激素发挥作用。鉴于越来越多的证据表明自噬过程失调与包括神经退行性变、代谢紊乱和癌症在内的不同病理状况相关，我们在此旨在描述神经肽在自噬调控中所发挥作用及其分子机制的最新进展。
