Hospital Psiquiátrico Infantil Juan N Navarro, Secretaría de Salud, Avenida San Buenaventura 86, Colonia Belisario, Domínguez, 14080, Mexico City, Mexico.
Research in Genetic, Clinical and Community Epidemiology, Mexico City, Mexico.
J Autism Dev Disord. 2017 Sep;47(9):2911-2917. doi: 10.1007/s10803-017-3175-4.
Autism spectrum disorders (ASD) may present with macrocephaly. Few studies have analyzed the association with psychiatric comorbidity. Participants were 94 children with any ASD with an age range from 2 to 16 years (Mdn 6 years), 82% were boys. It was found that 20% of the sample had macrocephaly and 1% microcephaly. There was no association between the presence of macrocephaly and subtype of ASD. The most associated comorbidity was attention-deficit/hyperactivity disorder (ADHD) 54.2%, followed by specific phobia 34%, dysthimia 29.7%, oppositional defiant disorder 13.83% motor tics 11.7%, separation anxiety 9.5% and Gilles de la Tourette 8.5%. In conclusion, macrocephaly and psychiatric comorbidity in this clinical sample of children with ASD is similar to the international literature results.
自闭症谱系障碍（ASD）可能表现为大头畸形。很少有研究分析其与精神共病的关系。参与者为 94 名年龄在 2 至 16 岁之间（中位数 6 岁）的任何 ASD 儿童，其中 82%为男孩。结果发现，该样本中有 20%存在大头畸形，1%存在小头畸形。大头畸形的存在与 ASD 的亚型之间没有关联。最相关的共病是注意力缺陷/多动障碍（ADHD）54.2%，其次是特定恐惧症 34%、心境恶劣 29.7%、对立违抗障碍 13.83%、运动性抽动 11.7%、分离焦虑 9.5%和 Gilles de la Tourette 8.5%。总之，本临床 ASD 儿童样本中大头畸形和精神共病与国际文献结果相似。
