a Life Sciences Institute , University of Michigan , Ann Arbor , MI , USA.
Autophagy. 2017 Aug 3;13(8):1259-1261. doi: 10.1080/15548627.2017.1327512.
Mitophagy is a conserved and highly regulated process of selective degradation crucial in maintaining normal cellular physiology. Genetic defects and cellular aberrations affecting mitophagy have been associated with the development of Parkinson disease. In their recently published article (highlighted in a punctum in this issue of the journal) Hsieh et al. present a putative mitophagy marker, which serves as a mechanistic link between sporadic and familial Parkinson disease.
自噬是一种保守且高度调控的选择性降解过程，对维持正常细胞生理至关重要。影响自噬的遗传缺陷和细胞异常与帕金森病的发展有关。在他们最近发表的文章中（本文档该期的一个亮点），Hsieh 等人提出了一个潜在的自噬标志物，它是散发性和家族性帕金森病之间的机制联系。
