苯二氮䓬类药物在抑郁症中的应用。
The use of benzodiazepines in depression.
作者信息
Johnson D A
出版信息
Br J Clin Pharmacol. 1985;19 Suppl 1(Suppl 1):31S-35S. doi: 10.1111/j.1365-2125.1985.tb02740.x.
Abstract
In clinical practice the benzodiazepines are prescribed almost as frequently as the tricyclic antidepressants for the treatment of depression. The therapeutic effects of the benzodiazepines and tricyclic antidepressants in depression have been compared in only 29 double-blind studies. The antidepressants proved overwhelmingly superior with only one study (alprazolam) even suggesting a possible parity of action. A symptom response analysis failed to show any true antidepressant action for the benzodiazepines. No clear indication for the use of a combination of drugs was revealed, although certain symptoms may show a more rapid response initially with combination therapy.
摘要
在临床实践中，苯二氮䓬类药物在治疗抑郁症时的处方频率几乎与三环类抗抑郁药相同。仅在29项双盲研究中比较了苯二氮䓬类药物和三环类抗抑郁药在抑郁症治疗中的疗效。结果证明抗抑郁药具有压倒性的优势，只有一项研究（阿普唑仑）甚至表明可能存在作用相当的情况。症状反应分析未能显示苯二氮䓬类药物有任何真正的抗抑郁作用。尽管联合治疗可能会使某些症状最初显示出更快的反应，但未发现使用联合药物的明确指征。
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